Actively Recruiting
Lactated Ringer's and Dextrose 5% vs Only Lactated Ringer's in Labor
Led by Eastern Virginia Medical School · Updated on 2025-08-22
158
Participants Needed
2
Research Sites
25 weeks
Total Duration
On this page
Sponsors
E
Eastern Virginia Medical School
Lead Sponsor
U
University of Modena and Reggio Emilia
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to determine which of two types of standard intravenous (IV) fluids (a combination of 5% dextrose and Lactated Ringers solution and Lactated Ringers solution alone) has a better influence on labor when inducing labor in pregnant women. The main questions it aims to answer are: 1. Does the use of 5% dextrose and Lactated Ringers lead to a shorter labor than the use of just Lactated Ringers? 2. Does the use of 5% dextrose and Lactated Ringers increase the risk of neonatal hypoglycemia when compared to Lactated Ringers? Participants in this trial will be randomly assigned to one of two groups: a group that receives a solution of 5% dextrose and Lactated Ringers, and a group that receives Lactated Ringers alone. Researchers will compare the outcomes of the two groups to see which IV fluid is more effective.
CONDITIONS
Official Title
Lactated Ringer's and Dextrose 5% vs Only Lactated Ringer's in Labor
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Nulliparous women
- Age 18 years or older and able to provide informed consent
- Singleton pregnancy at term
- Induction of labor
- Cephalic presentation
- Unfavorable cervix (Bishop score 64 6)
You will not qualify if you...
- Age under 18 years
- Involuntarily confined or detained
- Considered as having diminished decision-making capacity
- Spontaneous labor (cervical exam between 5-6 cm) with or without ruptured membranes
- Favorable cervix (Bishop score �3E6)
- Diabetes mellitus (both gestational and pre-gestational)
- Structural renal disease
- Acute or chronic kidney disease resulting in abnormal creatinine or proteinuria
- Evidence of chorioamnionitis or non-reassuring fetal testing at the time of enrollment
- Pyrexia (�3E38.0 degrees Celsius)
- Stillbirth
- Planned cesarean delivery
- Women presenting with emergent circumstances for labor induction
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Sentara Norfolk General Hospital
Norfolk, Virginia, United States, 23507
Actively Recruiting
2
Policlinico di Modena
Modena, Italy
Actively Recruiting
Research Team
T
Tetsuya Kawakita, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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