Actively Recruiting
Lactic Acidosis and Prior Metformin Treatment
Led by University Hospital, Strasbourg, France · Updated on 2025-12-23
100
Participants Needed
1
Research Sites
77 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Metformin is a drug frequently prescribed to patients with type 2 diabetes. Furthermore, diabetes can lead to micro- and macrovascular complications that may cause chronic organ failure. The presence of diabetes also increases the risk of infections. All of these factors contribute to the frequent admission of patients to the ICU who have been receiving metformin treatment in the preceding days. Acute renal failure, which is also frequently observed upon admission to the ICU, increases the risk of metformin overdose. In cases of overdose, metformin acts on several metabolic pathways that can lead to or even accelerate metabolic acidosis, sometimes severe. However, the impact on prognosis is controversial. The role of metformin in lactic acidosis in patients treated for acute illness may be underestimated in routine practice. This study aims to investigate the impact of prior metformin treatment on ICU survival in patients admitted to the ICU with severe lactic acidosis.
CONDITIONS
Official Title
Lactic Acidosis and Prior Metformin Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patient (≥18 years)
- Admitted to the intensive care unit of Hautepierre Hospital - Strasbourg University Hospital between January 1, 2014, and December 31, 2023
- Experienced lactic acidosis (pH <7.35 and lactate level ≥5 mmol/L) within the first 24 hours of hospitalization
You will not qualify if you...
- No arterial blood gas measurements during the first 24 hours of admission
- Unknown or undeterminable background treatment
- Limitation of active therapies before or during the first 24 hours of hospitalization
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Service de Médecine Intensive - Réanimation - CHU de Strasbourg - France
Strasbourg, France, 67091
Actively Recruiting
Research Team
V
Vincent CASTELAIN, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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