Actively Recruiting
Language, Speech and Motor Function in MCI Due to AD and Alzheimer's Disease
Led by Hanze University of Applied Sciences Groningen · Updated on 2024-07-18
208
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
Sponsors
H
Hanze University of Applied Sciences Groningen
Lead Sponsor
U
University of Groningen
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational cross-sectional study is to explore the characteristics of language, speech, and motor function in persons with Mild Cognitive Impairment due to Alzheimer's disease ("MCI due to AD") and persons with mild and moderate Alzheimer's disease ("AD"). This study aims to: * Explore motor, speech, and language functions in MCI due to AD and mild and moderate AD. * Combine the characteristics of motor, language, and speech functions to gain more insight into the association of language, speech, and motor changes during MCI due to AD and mild and moderate AD. Researchers will compare the outcomes to an age-matched control group without cognitive impairment. Participants will undergo: * Two motor function tests to assess gait and hand grip strength. * Four language and speech function tests to assess spontaneous speech and verbal fluency..
CONDITIONS
Official Title
Language, Speech and Motor Function in MCI Due to AD and Alzheimer's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Mild Cognitive Impairment due to Alzheimer's disease with likelihood according to NIA-AA criteria
- Global Deterioration Scale (GDS) score of 3 for MCI due to AD
- Diagnosis of Alzheimer's disease (amnestic or non-amnestic) or mixed AD according to DSM-5 or NINCDS-ARDRA criteria
- GDS score of 4 for mild AD or 5 for moderate AD
- Control group participants with GDS score of 1 or 2 and age-matched to MCI or AD patients
- First language must be Dutch and/or Frisian
- Ability to walk independently with or without a walking aid
- Ability to squeeze with each hand
You will not qualify if you...
- Neurological or neurodegenerative diseases or disorders contributing to cognitive impairment beyond AD or mixed AD (e.g., Down's syndrome, other dementia types, autism spectrum disorder)
- Established psychiatric disorders such as schizophrenia or depression
- Control group participants with neurological, neurodegenerative, or psychiatric diseases or disorders
- Hearing loss affecting communication, with or without hearing aid
- Vision loss affecting communication, with or without glasses or lenses
- History of language, speech problems, or dyslexia
- Disorders or diseases limiting gait, hand grip strength, language, or speech
- Use of medication influencing gait, hand grip strength, speech, or language at time of testing
- Being terminally ill with life expectancy less than 2 weeks according to attending physician
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hanze University
Groningen, Netherlands, 9714CA
Actively Recruiting
Research Team
M
Marlies Oegema, Master
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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