Randomized Trial Comparing Low Pressure in Laparoscopic Colorectal Resection With Warm and Humidified Carbon Dioxide Pneumoperitoneum Versus Low Pressure Pneumoperitoneum Alone

What this Trial Is About

Researchers are studying the effects of using low-pressure pneumoperitoneum combined with warm and humidified carbon dioxide gas during laparoscopic colorectal surgery. This approach aims to reduce post-operative pain without the use of opioid painkillers. The trial compares this method to the standard low-pressure laparoscopy using cold and dry gas in patients undergoing colorectal surgeries for benign or malignant conditions. Participants receive one of two treatments during surgery: either low-pressure pneumoperitoneum with warm (35°C), humidified (95% relative humidity) CO2 gas or low-pressure pneumoperitoneum with standard room temperature, dry CO2 gas. The low pressure used is between 5 and 8 mmHg. This trial is double-blind and randomized to fairly assess the impact of these two approaches on post-operative recovery. During the study, participants will be closely monitored for pain levels 24 hours after surgery using a visual analog scale (VAS) without opioid use. Additional assessments include surgery length, heart rate, blood pressure, temperature changes, inflammation markers, bowel function recovery, surgical complications, hospital stay duration, quality of life, and analgesic use up to 30 days after surgery. Follow-up extends to three months for longer-term outcomes related to pain, opioid use, and recovery.

Laparoscopic Colorectal Surgery Using Low-pressure Combined With Warm and Humidified Carbon Dioxide Insufflation