Actively Recruiting
Feasibility, Safety and Short-term Oncosurgical Outcome of Laparoscopic Pancreaticoduodenectomy for Malignancy: A Single Centre Experience
Led by Minia University · Updated on 2025-08-29
30
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating laparoscopic pancreaticoduodenectomy (LPD), a minimally invasive surgical technique used to treat pancreatic and periampullary cancers as well as other related conditions. The study aims to assess the safety, feasibility, and short-term oncological outcomes of LPD, a complex and technically demanding procedure that involves removing parts of the pancreas and surrounding structures. Although open pancreaticoduodenectomy has been the standard treatment, laparoscopic surgery is being explored as a less invasive alternative with the potential to reduce complications. The study involves performing laparoscopic pancreaticoduodenectomy using a 6-port technique with specific patient positioning and surgical steps such as vessel ligation, lymphadenectomy, and reconstruction of digestive tract connections. Surgeons use advanced tools like harmonic scalpels, Ligasure, and staplers during the procedure. This approach is applied only if no vascular invasion or metastasis is detected. The study focuses on patients with resectable pancreatic head cancer, cholangiocarcinoma, duodenal cancer, and ampullary tumors who are fit for this surgery. Participants undergo careful screening to confirm eligibility and avoid inoperable or metastatic cases. Researchers assess surgical specimens pathologically within 1 to 2 weeks after surgery and monitor outcomes including pancreatic fistula rates, operative time, blood loss, blood transfusions, length of hospital stay, and intensive care unit duration over up to 90 days. The study collects detailed data to evaluate the short-term safety and effectiveness of laparoscopic pancreaticoduodenectomy for cancer treatment.
CONDITIONS
Brief Title
Laparoscopic Pancreaticoduodenectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients meeting curative treatment intent according to clinical guidelines
- No evidence of metastasis
- No radiological involvement of superior mesenteric vein and portal vein
- Preserved fat planes between celiac axis, hepatic artery, and superior mesenteric artery
- Patients with resectable pancreatic head cancer, cholangiocarcinoma, duodenal cancer, or ampullary tumors
- Patients fit for laparoscopic pancreaticoduodenectomy
- Age between 18 and 75 years
You will not qualify if you...
- Patients unfit for surgery due to severe medical illness
- Patients with distant metastases including peritoneal, liver, or distant lymph node metastases
- Patients with involvement of other organs making surgery inoperable
- Patients with irresectable tumors found in diagnostic laparoscopy
- Patients requiring other surgeries such as left, central, or total pancreatectomy or palliative surgery
- History of other malignant diseases
- Pregnant or breastfeeding women
- Patients with serious mental disorders
- Patients with vascular invasion requiring vascular resection
- Patients undergoing pancreatoduodenectomy for benign cystic lesions, benign tumors, or chronic calcific pancreatitis
- Patients with cirrhotic liver
- Patients who refuse to participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day 0 up to 90 days post-surgery
Participants undergo laparoscopic pancreaticoduodenectomy, a minimally invasive surgery involving complex dissection and reconstruction of the pancreas area.
Hospital stay including surgery and postoperative surgical intensive care unit stay
Duration - Up to 4 weeks post-surgery
Participants are monitored for surgical outcomes including pancreatic fistula rate and recovery progress after surgery.
Approximately 1 to 2 visits post-surgery
Trial Site Locations
Total: 1 location
1
Liver and GIT hospital , Minia University
Minya, Egypt, 61519
Actively Recruiting
Research Team
S
Saleh K Saleh, MD
R
Rabeh K Saleh, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here