Actively Recruiting
Large Artery Occlusion Treated in Extended Time With Mechanical Thrombectomy Trial
Led by The George Institute for Global Health, China · Updated on 2026-03-06
382
Participants Needed
1
Research Sites
282 weeks
Total Duration
On this page
Sponsors
T
The George Institute for Global Health, China
Lead Sponsor
C
Changhai Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
A multi-center, prospective, randomized, open-label, adaptive group sequential designed, blinded endpoint assessment (PROBE) clinical trial of endovascular treatment among selected AIS
CONDITIONS
Official Title
Large Artery Occlusion Treated in Extended Time With Mechanical Thrombectomy Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Stroke occurred 24 to 72 hours before enrollment
- Clinical diagnosis of acute ischemic stroke due to large vessel occlusion in the anterior brain circulation
- NIH Stroke Scale score of 6 or higher at randomization
- Evidence of viable brain tissue on CT or MRI perfusion scans with infarct core volume less than 50 mL, mismatch ratio 1.8 or higher, and mismatch volume 15 mL or higher
- Written informed consent obtained from patient or proxy
You will not qualify if you...
- Unlikely to benefit from the trial due to conditions like advanced dementia, major pre-stroke disability, or high chance of early death
- Major co-existing diseases that affect follow-up or outcomes (e.g., cancer, severe heart or kidney failure)
- Pregnancy
- Unable to undergo CT or MRI perfusion imaging
- Known allergy to iodine, heparin, anesthesia, or contraindication to endovascular treatment
- Seizures at stroke onset or before randomization preventing accurate stroke severity assessment
- Extremely low or high blood glucose levels at baseline
- Low platelet count below 50,000 per microliter
- Known bleeding disorders or recent anticoagulant therapy with high INR
- Severe high blood pressure (systolic >220 mmHg or diastolic >120 mmHg)
- Suspected septic embolus or bacterial endocarditis
- Previous endovascular treatment attempted for current stroke
- Unlikely to participate in follow-up assessments
- Currently enrolled in another clinical trial affecting outcomes
- Other conditions posing significant risk as judged by the investigator
- Presence of intracranial hemorrhage or brain tumor (except small meningioma)
- Significant brain swelling with midline shift
- Aortic dissection
- Intracranial stent in the same vascular territory
- Vascular anatomy preventing safe or effective endovascular treatment
- Multiple vessel occlusions confirmed on imaging (e.g., bilateral MCA occlusions)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Changhai Hospital
Shanghai, China
Actively Recruiting
Research Team
L
Lily Song, PhD
CONTACT
C
Craig Anderson, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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