Actively Recruiting
Large Granular Lymphocytes in mNSCLC Treated With Nivolumab
Led by Necmettin Erbakan University · Updated on 2026-01-26
50
Participants Needed
1
Research Sites
100 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Large granular lymphocytes (LGLs), which constitute 10-15% of peripheral blood mononuclear cells, are large lymphocytes with a round nucleus, large cytoplasm, and azurophilic granules in the cytoplasm. Most normal LGLs in peripheral blood are natural killer (NK) cells, but some are T lymphocytes. These cells cannot be measured by a standard complete blood count (CBC) test. These cells, which can be detected by peripheral smear, are expressed numerically and as a percentage relative to other cells. The aim of this study is to determine the relationship between the percentage of LGLs at baseline and at three months and the response and clinical parameters in participants with metastatic non-small cell lung cancer treated with nivolumab in second-line therapy.
CONDITIONS
Official Title
Large Granular Lymphocytes in mNSCLC Treated With Nivolumab
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histological and staging diagnosis of metastatic non-small cell lung cancer
- ECOG performance score between 0 and 2
- No contraindications for nivolumab
You will not qualify if you...
- Patients diagnosed with metastatic NSCLC who received nivolumab as adjuvant or perioperative therapy
- Patients with a second primary malignancy undergoing active treatment
- Patients who have not signed the informed consent form
- Patients with additional hematological malignancies such as leukemia, lymphoma, or myelodysplastic syndrome
- Patients who have undergone palliative or curative radiotherapy within the last three months
- Patients with active viral or bacterial infections before nivolumab treatment
- Patients who have used steroids in the last three months
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Necmettin Erbakan University Faculty of Medicine, Department of Medical Oncology
Konya, Meram, Turkey (Türkiye), 42090
Actively Recruiting
Research Team
A
Ahmet Oruç MD
CONTACT
M
Mehmet Artaç MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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