Actively Recruiting
Laryngoscopy for Neonatal and Infant Airway Management wIth Supplemental Oxygen at Different Flow Rates (OPTIMISE-2)
Led by Thomas Riva · Updated on 2026-05-12
1192
Participants Needed
11
Research Sites
195 weeks
Total Duration
On this page
Sponsors
T
Thomas Riva
Lead Sponsor
U
University Hospital, Geneva
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to investigate the optimal oxygen flow rate needed during tracheal intubation with the C-MAC video laryngoscope (Karl Storz, Tuttlingen, Germany) using Miller-blade or Macintosh-blade size No. 0 or No. 1 in the operating room or intensive care unit. The investigators hypothesize that the difference between low-flow and high-flow supplemental oxygen is negligible.
CONDITIONS
Official Title
Laryngoscopy for Neonatal and Infant Airway Management wIth Supplemental Oxygen at Different Flow Rates (OPTIMISE-2)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pediatric patients requiring oral or nasal tracheal intubation for elective, semi-elective, or urgent surgical and non-surgical indications
- Neonates and infants up to 52 weeks postconceptual age
- Legal guardians must provide written informed consent before the intervention
You will not qualify if you...
- Predicted difficult intubation requiring a technique other than direct laryngoscopy
- Congenital heart disease requiring less than 100% oxygen (FiO2 < 1.0)
- Cardiopulmonary collapse needing advanced life support
- Intubation for emergency surgical and non-surgical reasons
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 11 locations
1
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
2
Perth Children's Hospital
Perth, Western Australia, Australia, 6009
Actively Recruiting
3
Hospital Municipal Infantil Menino Jesus, Servicos Medicos de Anestesia
São Paulo, São Paulo, Brazil
Actively Recruiting
4
Dept. Anesthesia, The Hospital for Sick Children
Toronto, Ontario, Canada
Actively Recruiting
5
Dept. Anesthesia, Montreal Children's Hospital, McGill University Health Centre
Montreal, Canada
Actively Recruiting
6
Department of Cardiac Anesthesiology and Intensive Care Medicine, Charité Universitätsmedizin
Berlin, Germany
Actively Recruiting
7
IRCCS Istituto Giannina Gaslini
Genova, Italy, 16147
Actively Recruiting
8
Kantonsspital Aarau, KSA
Aarau, Canton of Aargau, Switzerland
Actively Recruiting
9
Luzerner Kantonsspital
Lucerne, Canton of Lucerne, Switzerland, 6004
Actively Recruiting
10
Inselspital
Bern, Switzerland, 3010
Actively Recruiting
11
CHUV Centre Hospitalier Universitaire Vaudois
Lausanne, Switzerland, 1011
Active, Not Recruiting
Research Team
A
Alexander Fuchs, MD
CONTACT
T
Thomas Riva, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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