A Clinical Trial Evaluating Laser Interstitial Thermal Ablation Combined With Spine Stereotactic Radiosurgery for Patients With Spine Metastases

What this Trial Is About

Researchers are evaluating a combination of spinal interstitial laser ablation and stereotactic spine radiosurgery SSRS to treat spinal tumors near the spinal cord, especially in patients with spinal metastasis that includes an epidural component. The study aims to improve tumor control, pain relief, preserve function, and enhance quality of life while documenting safety and accuracy of MRI-compatible hardware used for image guidance. This research measures how effective these combined treatments are compared to historical controls using SSRS alone. Participants will receive laser interstitial thermal ablation and CT-guided stereotactic radiosurgery, delivered via intensity-modulated radiation therapy, on separate days within a one to fourteen day window. The order of treatments is decided by the treating physician. Surgery occurs in an intraoperative suite equipped with an operating room and MRI scanner to guide the laser ablation precisely. During the study, participants will have regular assessments including MRI scans to monitor tumor control and epidural tumor regression at multiple time points up to 24 months. Researchers will also evaluate overall survival, muscle strength, pain levels, sensory and neurological function, ability to walk, and quality of life using validated tools. Adverse events will be tracked and correlated with imaging and symptom changes. The study involves ongoing follow-up visits for up to two years after treatment to measure outcomes and safety.

Laser Interstitial Thermal Ablation and Stereotactic Radiosurgery for Patients With Spine Metastases