Actively Recruiting
Laser Interstitial Thermal Therapy (LITT) or Surgery and Adjuvant Reirradiation for Recurrent Brain Metastases (LaSAR BeaM)
Led by M.D. Anderson Cancer Center · Updated on 2026-03-09
155
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
standard paradigm for management of patients who present with concern for recurrence of brain metastases following initial stereotactic radiosurgery (SRS).
CONDITIONS
Official Title
Laser Interstitial Thermal Therapy (LITT) or Surgery and Adjuvant Reirradiation for Recurrent Brain Metastases (LaSAR BeaM)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to understand and willing to sign informed consent
- Willingness to comply with all study procedures and be available for study duration
- Age 18 years or older
- Karnofsky performance status of 60 or higher
- Radiographic concern for progression of solid tumor brain metastasis treated with prior stereotactic radiosurgery at least 3 months ago
- Measurable disease with at least one lesion 5 mm or larger on MRI
- Active tumor confirmed on pathology from surgery or LITT
- Able to safely undergo MRI imaging
- Acceptable candidate for second stereotactic radiosurgery (SRS2) per physician and multidisciplinary team
- No radiographic evidence of leptomeningeal disease
- Prior or concurrent malignancy allowed if it does not interfere with safety or efficacy assessments
You will not qualify if you...
- Brain metastases from hematologic malignancies
- Psychiatric illness or social situations limiting compliance with study requirements
- Pregnant women due to radiation risks
- Females between onset of menses and 55 years without negative pregnancy test unless postmenopausal, history of hysterectomy or bilateral salpingo-oophorectomy, ovarian failure, or surgical sterilization
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The University of Texas M. D. Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
S
Subha Perni, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
3
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