Actively Recruiting
Laser Therapy in the Isotretinoin-Induced Sacroiliitis
Led by Uşak University · Updated on 2025-12-12
50
Participants Needed
1
Research Sites
24 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The clinical significance of this adverse effect lies in its impact on quality of life and the potential for misdiagnosis. The symptomatology can be severe enough to limit daily activities and may be mistakenly attributed to a primary rheumatic disease, leading to unnecessary long-term immunosuppressive therapy if the temporal link to isotretinoin is not identified. Therefore, a high index of suspicion is crucial for dermatologists, rheumatologists, and primary care physicians alike. Aim: To compare the effectiveness of High-Intensity Laser Therapy (HILT) in reducing pain intensity, in patients diagnosed with Isotretinoin-Induced Sacroiliitis.
CONDITIONS
Official Title
Laser Therapy in the Isotretinoin-Induced Sacroiliitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged between 18 and 35 years.
- Receiving a stable dose of oral isotretinoin (0.3-0.5 mg/kg/day) for at least one month.
- Diagnosed with sacroiliitis based on persistent lower back or buttock pain lasting 4 or more weeks, morning stiffness over 30 minutes, and improvement with exercise.
- At least two positive sacroiliac joint provocation tests (e.g., FABER/Patrick's test, Gaenslen's test, Compression/Distraction test).
- Radiological confirmation of active inflammation in one or both sacroiliac joints by MRI STIR sequences.
- Baseline pain intensity of 4 or higher on the Visual Analog Scale (0-10 cm).
You will not qualify if you...
- Diagnosis of ankylosing spondylitis or other seronegative spondyloarthritis.
- Pregnancy.
- Presence of any cancer.
- Presence of multiple sclerosis.
AI-Screening
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Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Usak
Uşak, Turkey (Türkiye), 64200
Actively Recruiting
Research Team
A
Ali Y Karahan, Professor
CONTACT
K
Kagan Ozkuk, Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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