Actively Recruiting
LAssa Fever Adjunct Treatment With DEXamethasone
Led by Bernhard Nocht Institute for Tropical Medicine · Updated on 2025-02-06
42
Participants Needed
1
Research Sites
147 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Dexamethasone is a corticosteroid which can modulate inflammatory-mediated tissue damage associated with a wide range of infectious diseases. Dexamethasone is routinely used for treatment of tuberculous meningitis and for pneumococcal meningitis in adults. In Coronavirus Disease 2019 (COVID-19) dexamethasone is also effectively preventing immune mediated damage of the lungs. There is also indication that dexamethasone may be promising in severe LF.
CONDITIONS
Official Title
LAssa Fever Adjunct Treatment With DEXamethasone
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Lassa fever confirmed by RT-PCR with a cycle threshold value below 30
- Signs of significant health impairment including altered alertness, low blood pressure (systolic below 90 mmHg), seizures, meningism, coma, or focal neurological deficit
- Elevated liver enzymes AST or ALT over three times the upper limit of normal
- Kidney injury stage KDIGO 2 or higher based on serum creatinine
- Active visible bleeding
- Oxygen saturation below 92%
You will not qualify if you...
- Pregnancy as confirmed by a positive urine pregnancy test in women of child-bearing potential
- Breastfeeding after live birth
- Known intolerance or contraindications to ribavirin or dexamethasone
- Use of corticosteroids within 7 days before enrollment
- Investigator judgment that participation poses substantial risk
- Receiving end-of-life care as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Irrua Specialist Teaching Hospital
Irrua, Edo, Nigeria
Actively Recruiting
Research Team
M
Mirjam Groger, Dr.
CONTACT
S
Stephan Günther, Prof.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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