Actively Recruiting
LATe Cerclage in High-risk Pregnancies (LATCH)
Led by Thomas Jefferson University · Updated on 2025-04-16
329
Participants Needed
1
Research Sites
272 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to determine whether cervical cerclage reduces the risk of preterm birth in patients with a short transvaginal ultrasound (TVU) cervical length (CL) ≤25mm between 24 0/7-26 6/7 weeks.
CONDITIONS
Official Title
LATe Cerclage in High-risk Pregnancies (LATCH)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant women aged 18 to 50 years
- Assigned female at birth
- Singleton pregnancy
- Short cervical length (25 mm or less) measured by transvaginal ultrasound between 24 0/7 and 26 6/7 weeks of gestation
You will not qualify if you...
- Initial multifetal pregnancy with reduction or selective termination after 14 weeks, or cotwin pregnancy loss after 14 weeks
- Cervical cerclage already in place
- Signs of preterm labor such as painful regular contractions and cervical change
- Preterm premature rupture of membranes (PPROM)
- Active vaginal bleeding
- Suspected infection inside the amniotic sac
- Major fetal structural abnormality or chromosomal disorder
- Placenta previa or placenta accreta
- Any other reason that makes cerclage placement unsafe
- Participation in another clinical trial related to preterm birth prevention, cerclage, or progesterone
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Thomas Jefferson University
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
Research Team
M
Moti Gulersen, MD, MSc
CONTACT
V
Vincenzo Berghella, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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