Actively Recruiting
Late-Onset Seizures: Trial of Vascular Risk Investigation and Treatment
Led by Sahlgrenska University Hospital · Updated on 2026-03-03
420
Participants Needed
3
Research Sites
508 weeks
Total Duration
On this page
Sponsors
S
Sahlgrenska University Hospital
Lead Sponsor
S
Sodra Alvsborgs Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
A growing body of evidence suggests patients with late-onset seizures are at an increased risk of stroke, but the potential for reducing cardiovascular morbidity through risk factor screening and management is unknown. The investigators aim to determine whether individuals with new-onset unprovoked seizures after middle age should undergo vascular risk assessment. In a cluster project the investigators assess the effect of vascular risk factor screening in an observational study as well as a cohort study. The project has two interlinked components: a prospective single group study, in which risk factor assessment is performed and subsequent management is followed for one year; and a register-based cohort study examining the long-term effects of the intervention on a system level.
CONDITIONS
Official Title
Late-Onset Seizures: Trial of Vascular Risk Investigation and Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- First assessment for unprovoked seizures or epilepsy with onset after age 50 with vascular risk factor evaluation at participating care providers
- Age 50 or older with a first-ever outpatient appointment to one of the participating clinics
- First-listed diagnostic code for seizures or epilepsy (ICD-10: R568, G40)
You will not qualify if you...
- Inability to provide consent
- Progressive brain disease such as tumor or degenerative disorders
- Preexisting seizures or epilepsy diagnosed more than 3 months before initial consultation
- Prior stroke or transient ischemic attack before initial consultation
- Progressive brain disease indicated by diagnostic codes or drug prescriptions for brain tumors
- Neurocognitive disorders based on specific diagnostic codes or medications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Södra Älvsborg Sjukhus
Borås, Sweden
Actively Recruiting
2
Salgrenska University Hospital
Gothenburg, Sweden
Actively Recruiting
3
Skånes universitetssjukhus
Malmö, Sweden
Actively Recruiting
Research Team
J
Johan Zelano, MD PhD
CONTACT
D
David Larson, MD PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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