Study of Adding Side-Lying Positions to Prone Position to Improve Lung Function in Adults with Moderate to Severe ARDS

What this Trial Is About

Researchers are investigating how adding repeated 30-minute periods of 30 side positioning lateralization affects lung air flow in patients with moderate to severe acute respiratory distress syndrome ARDS. This study focuses on comparing lung aeration in both lying on the back supine and lying face down prone positions. The goal is to see if lateral positioning combined with prone positioning can improve oxygen flow better than prone positioning alone. The study involves patients initially lying in a supine position, followed by alternating 30-minute sessions of side-lying on each side with a 30 tilt, totaling one hour. Then, patients will be placed in a prone position for six hours, followed by 12 hours of the same alternating side-lying while still prone. After returning to the supine position, there will be a one-hour observation before final measurements. The entire intervention lasts about 20 hours. Participants will undergo detailed lung function assessments using electrical impedance tomography to measure lung aeration and tidal volume changes. Researchers will also evaluate gas exchange and lung blood flow during each positioning phase. Measurements include oxygen and carbon dioxide levels, lung pressure parameters, and any side effects from lateral positioning. The studys total observation time is up to 25 hours, and safety is monitored throughout the intervention.

Lateral Positioning and Prone Positioning in ARDS Patients