Actively Recruiting
Lateral Positioning and Prone Positioning in ARDS Patients
Led by Centre Hospitalier de Bastia · Updated on 2025-05-15
20
Participants Needed
2
Research Sites
100 weeks
Total Duration
On this page
Sponsors
C
Centre Hospitalier de Bastia
Lead Sponsor
C
Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Collaborating Sponsor
AI-Summary
What this Trial Is About
Lateral (30°) and alternating positioning (change of side every 30 minutes) carried out on specific beds, could be an alternative or complement to prone positioning (PP) in ARDS patients. The combination of lateralization in prone position has not been studied. The dynamic created by lateralization could allow better overall ventilation during PP, thus making it possible to further improve oxygenation. The main objective of this prospective, bicentric, open, single group study with repeated measures will be to demonstrate that the addition of repeated 30-minute periods of 30° lateralization improves pulmonary aeration in the supine and prone positions in patients with moderate to severe ARDS.
CONDITIONS
Official Title
Lateral Positioning and Prone Positioning in ARDS Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age of at least 18 years
- ARDS evolving for less than 5 days with a PaO2/FiO2 ratio below 150 after optimization of PEEP, curarization, and no prior use of prone positioning since intubation
- Written consent obtained from the patient or authorized representative
- Beneficiary of health insurance coverage
- Ability to participate in other studies that do not interfere with this study's evaluation criteria
You will not qualify if you...
- Refusal to participate
- Pregnant, parturient, or breastfeeding women
- Intracranial pressure above 30 mm Hg or cerebral perfusion pressure below 60 mmHg
- Severe chronic respiratory disease requiring home oxygen or mechanical ventilation (except CPAP/BIPAP for sleep apnea)
- Chronic interstitial lung diseases
- Patients on ECMO
- Weight over 100 kg
- Severe liver disease with Child-Pugh score 12-15
- Pneumothorax
- SAPS II score above 75 at inclusion
- Unstable spinal fracture
- Contraindications to electrical impedance tomography (pacemaker, implantable defibrillator, skin lesions between 4th and 5th ribs)
- Withdrawal or withholding treatment decision (except for ECMO)
- Any other condition interfering with study evaluation
- Legal protection measures (guardianship, curatorship)
- Detained persons by judicial or administrative decision
- Inability to complete the 25-hour intervention due to worsening condition requiring ECMO, death, or organizational problems
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Bastia General Hospital
Bastia, France, France, 20604
Actively Recruiting
2
North Hospital Marseille
Marseille, France, France, 13915
Actively Recruiting
Research Team
L
Laurent Papazian, MD,PHD
CONTACT
A
Antoine Faure, PH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
1
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