Actively Recruiting
LcProt: Longitudinal Cohort Study Using Tissue and Blood Proteomics to Study Lung Cancer Diagnosis and Treatment
Led by The First Affiliated Hospital of Guangzhou Medical University · Updated on 2025-01-16
2500
Participants Needed
1
Research Sites
391 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting a longitudinal study to explore the role of proteomics in diagnosing and treating lung cancer. The study focuses on patients with lung nodules confirmed by CT scans and aims to evaluate proteomics at critical treatment time points, including screening, predicting postoperative outcomes, and assessing treatment efficacy over time. This research seeks to better understand how proteomics can distinguish between benign and malignant lung conditions and predict long-term prognosis. Participants will provide tissue samples obtained through biopsy or surgery and peripheral blood samples. These samples will undergo quantitative proteomics analysis using mass spectrometry. The study tracks changes at key moments during diagnosis and treatment to gather comprehensive data on therapeutic effectiveness and disease progression. During the study, participants will undergo CT scans and pulmonary function tests to monitor lung health. Researchers will collect and analyze proteomics data from blood and tissue samples to measure treatment outcomes and long-term prognosis. The study requires participants to have good preoperative pulmonary function and complete imaging reports, with a total participation age range of 18 to 75 years.
CONDITIONS
Official Title
LcProt: Proteomics Longitudinal Cohort Study on Lung Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent form
- Male or female aged 18 to 75 years
- Lung nodules confirmed by CT scan
- Good cooperation for preoperative pulmonary function tests with complete reports
- Preoperative chest single or dual phase CT scans without significant artefacts and complete imaging
- Interval between preoperative pulmonary function and CT scans no longer than one month
You will not qualify if you...
- Poor cooperation for preoperative pulmonary function tests or missing reports
- Preoperative chest CT scans with significant artefacts or missing images
- Interval between preoperative pulmonary function and CT scans longer than one month
- Severe respiratory disorders such as lung transplantation, pneumothorax, or giant bullae
- Other severe functional impairments
- Presence of obstructive lesions like airway or esophageal stenosis
- Medication use before pulmonary function testing not following cessation guidelines
- Pulmonary function report quality graded D to F
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
the First Affiliated of Guangzhou Medical University
Guangzhou, Guangdong, China, 510120
Actively Recruiting
Research Team
J
Jianxing He, Professor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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