Actively Recruiting
LDRT Combined With Pucotenlimab and Standard Therapy for Advanced Pancreatic Cancer: A Single-Arm Study
Led by Zhejiang Provincial People's Hospital · Updated on 2026-01-26
10
Participants Needed
1
Research Sites
56 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To investigate the activating effect of local lesion low-dose radiotherapy (2Gy) on the tumor immune microenvironment, and the efficacy, safety, and feasibility of its combination with pembrolizumab and standard therapy in patients with advanced pancreatic cancer. Concurrently, to preliminarily establish an efficacy prediction model for the early identification of patient populations who would benefit from the treatment, thereby providing a theoretical foundation for the implementation of precision medicine.
CONDITIONS
Official Title
LDRT Combined With Pucotenlimab and Standard Therapy for Advanced Pancreatic Cancer: A Single-Arm Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- ECOG performance score of 0 to 1
- Histologically or cytologically confirmed pancreatic cancer
- No prior treatment with PD-1 or PD-L1 inhibitors
- Presence of a tumor lesion eligible for radiotherapy (excluding bone metastases)
- Voluntary participation with signed informed consent
You will not qualify if you...
- Previous history of radiotherapy
- Uncontrolled chronic infectious or non-infectious diseases (e.g., medication-resistant heart failure, poorly controlled hypertension)
- Active or uncontrolled severe infections
- History of psychoactive drug abuse or psychiatric disorders
- Pregnant or breastfeeding women, or those unwilling or unable to use effective contraception
- Any other condition that may affect study conduct or result interpretation as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Zhejiang Provincial People's Hospital
Hangzhou, Zhejiang, China
Actively Recruiting
Research Team
L
Liu Yang, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here