Actively Recruiting
LEAN Mass Preservation With Resistance Exercise and Protein During Semaglutide/Tirzepatide Therapy
Led by Dasman Diabetes Institute · Updated on 2026-04-21
232
Participants Needed
1
Research Sites
229 weeks
Total Duration
On this page
Sponsors
D
Dasman Diabetes Institute
Lead Sponsor
U
University of Glasgow
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of the current study is to determine whether resistance exercise and/or protein intake can preserve lean mass and improve physical function in patients with obesity initiating semaglutide/tirzepatide therapy. To achieve this aim the study will have the following objectives. In people with obesity initiating semaglutide/tirzepatide therapy 1. Form a PPI group to refine the study protocol and establish study materials, 2. Quantify the effects of a pragmatic resistance exercise intervention and/or increasing protein intake on lean mass and physical function during semaglutide/tirzepatide induced weight loss, 3. Establish whether the resistance exercise intervention and/or increasing protein intake has concomitant benefits on glycaemic control, lipids, liver function, quality of life, physical activity and sleep during semaglutide/tirzepatide induced weight loss. The participants will: Begin their weight loss medication, starting at a low dose and then increasing the dose to maximize weight loss. They will be randomly assigned by a computer to ONE of the following groups and will be followed up to 6-months: * Control group * Protein intake group * Muscle strengthening exercise group * Muscle strengthening exercise AND protein intake group.
CONDITIONS
Official Title
LEAN Mass Preservation With Resistance Exercise and Protein During Semaglutide/Tirzepatide Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age �3;= 18 years
- BMI �3;= 27 kg/m2
You will not qualify if you...
- Currently or in the past 6 months participating in any vigorous aerobic activity (>1h per week) or any resistance exercise
- Blood pressure of 160/100 mmHg or higher
- Any known medical condition that prevents participants from exercising safely
- Personal or family history of medullary thyroid carcinoma
- Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- History of chronic or acute pancreatitis
- History of proliferative diabetic retinopathy or diabetic maculopathy
- History of ketoacidosis or hyperosmolar state/coma
- History of severe hypoglycaemia and/or hypoglycaemia unawareness within last 6 months
- Clinically significant gastric emptying abnormality or having undergone or planning to undergo gastric bypass or restrictive bariatric surgery or chronically taking drugs that affect GI motility
- Cardiovascular conditions in the last 2 months such as acute myocardial infarction, stroke, or hospitalization due to congestive heart failure
- History of NYHA IV congestive heart failure
- Acute or chronic hepatitis, liver disease signs/symptoms other than NAFLD, ALT > 3 times upper limit of normal
- eGFR <45 mL/min/1.73m2
- Significant uncontrolled endocrine abnormality
- Evidence of active autoimmune abnormality likely requiring systemic glucocorticoid treatment in next 12 months
- Had or waiting for an organ transplant
- History of active or untreated malignancy or remission from clinically significant malignancy for less than 5 years
- Any condition limiting ability to complete the study
- Treatment with prescription weight loss drugs in the last 3 months
- Receiving chronic systemic glucocorticoid therapy within last month
AI-Screening
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Trial Site Locations
Total: 1 location
1
Dasman Diabetes Institute
Kuwait City, Kuwait
Actively Recruiting
Research Team
D
Dr Ebaa Al Ozairi
CONTACT
P
Prof Stuart Gray
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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