Study of Left Bundle Branch Pacing Versus Dual-Chamber ICD in Adults With Hypertrophic Cardiomyopathy After Myectomy to Prevent Heart Failure and Rhythm Problems

What this Trial Is About

Researchers are evaluating the safety and effectiveness of left bundle branch pacing LBBP in patients with hypertrophic cardiomyopathy HCM who have undergone myectomy surgery and have complete left bundle branch block LBBB. The study aims to compare the outcomes of implanting a cardioverter-defibrillator ICD with LBB pacing versus a traditional dual-chamber ICD in patients at high risk of sudden cardiac death SCD. This pilot randomized trial will analyze various heart function measures, arrhythmia occurrences, and quality of life over time. Participants are randomly divided into two groups one receiving a dual-chamber ICD with LBB pacing and the other receiving a standard dual-chamber ICD. The LBB pacing procedure involves implanting electrodes into the interventricular septum near the His bundle to alter heart electrical activation, while the traditional ICD implantation follows standard pacemaker placement techniques. Both groups will undergo ICD programming and assessment at 3, 6, and 12 months after surgery. During the study, researchers will collect demographic and clinical data, including heart function tests, ECG measurements, blood markers like NT-proBNP, and quality of life questionnaires before surgery and 12 months afterward. They will monitor ICD function, complications, heart rhythm episodes, and heart remodeling through echocardiography and ECG at multiple follow-up visits. The study duration includes initial hospitalization and one year of monitoring to evaluate outcomes and safety.

Left Bundle Branch Pacing in Patients With Hypertrophic Cardiomyopathy After Myectomy