Evaluating Left Heart Recovery After Surgery for Aortic Valve Leakage in Patients with Functional Mitral Valve Leakage

What this Trial Is About

Researchers are studying how surgical treatment for chronic aortic regurgitation affects the hearts left ventricle, especially when combined with correction of functional mitral regurgitation. The study focuses on patients with severe enlargement of the left heart chambers. It aims to assess how mitral regurgitation influences the recovery and remodeling of the left ventricle after surgery, using echocardiography and quality of life measures. Participants are grouped based on the severity of their mitral regurgitation and whether they receive mitral valve repair during surgery. The groups include patients with mild to moderate mitral regurgitation without repair, severe mitral regurgitation without repair, mild to moderate mitral regurgitation with repair, and severe mitral regurgitation with repair. This observational study does not involve additional treatments but monitors outcomes over time. Throughout the study, participants will have their left ventricle volume and function evaluated by echocardiography at 3 and 12 months after surgery. Researchers will also track hospital readmissions within 12 months and assess quality of life at inclusion, 10 days post-surgery, and at 3 and 12 months. The study is sponsored by the Petrovsky National Research Centre of Surgery and will continue until May 2030.

Left Ventricular Reverse Remodeling Evaluation After Surgical Correction of Aortic Regurgitation