Actively Recruiting
Left Ventricular Reverse Remodeling Evaluation After Surgical Correction of Aortic Regurgitation
Led by Petrovsky National Research Centre of Surgery · Updated on 2025-06-11
120
Participants Needed
2
Research Sites
311 weeks
Total Duration
On this page
Sponsors
P
Petrovsky National Research Centre of Surgery
Lead Sponsor
V
Voronezh regional clinical hospital #1
Collaborating Sponsor
AI-Summary
What this Trial Is About
Investigators assume that surgical correction approach to functional mitral regurgitation during intervention for chronic aortic regurgitation in patients with severe enlargement of the left heart chambers influences reverse remodeling of the left ventricle (LV) in the postoperative period. It is suggested that functional mitral regurgitation (MR) provides supra-physiological left ventricle volume overload and this fact plays positive role in early-stage post-operative left ventricle volume and function recovery. LV volume, systolic and diastolic function will be monitored with echocardiography (EchoCG) along with life quality in patients with different grades of functional mitral regurgitation secondary to severe chronic aortic insufficiency after surgical treatment of aortic regurgitation.
CONDITIONS
Official Title
Left Ventricular Reverse Remodeling Evaluation After Surgical Correction of Aortic Regurgitation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 18 years
- Planned primary elective surgery for chronic aortic regurgitation
- Presence of functional mitral regurgitation
- End-diastolic volume of the left ventricle >= 250 ml
You will not qualify if you...
- Infectious endocarditis
- History of myocardial infarction
- Indications for simultaneous myocardial revascularisation
- Acute aortic regurgitation of any cause
- Previously diagnosed left ventricle dilatation not related to aortic regurgitation
- Long-term persistent or permanent atrial fibrillation
- Pregnancy within 12 months after surgery
- Participation in other studies at the same time
- Presence of implanted pacemakers
- Refusal to sign informed consent
- Acute coronary event within 12 months after aortic valve surgery
- Need for resynchronization therapy or permanent right ventricular pacing within 12 months after surgery
- Re-do cardiac surgery for any reason within 12 months after aortic valve surgery
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Petrovsky National Research Center of Surgery
Moscow, Russia, 119435
Actively Recruiting
2
Voronezh Regional Clinical Hospital No. 1
Voronezh, Russia, 394066
Actively Recruiting
Research Team
E
Eduard Charchyan, professor
CONTACT
A
Andrei Bulynin
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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