Study of Patients with Severe Limb Ischaemia to Assess One-Year Amputation Rates and Health Outcomes Including Frailty, Cognitive Function, and Heart Disease Assessments

What this Trial Is About

Researchers are investigating severe limb ischaemia SLI, a serious stage of peripheral arterial disease where blood flow to the limbs is severely reduced, causing pain, ulcers, or gangrene lasting at least two weeks. This study aims to determine how many patients undergo major lower limb amputation within 12 months and to compare outcomes to a past group of patients. It also examines frailty, cognitive impairment, heart disease through cardiac MRI, and collects samples for future biomarker studies to improve risk assessment of SLI patients. The study follows patients presenting with SLI at a vascular institute over two years, including those undergoing interventions for their condition. Various assessments are done such as frailty and cognitive tests for older patients, cardiac MRI scans for heart disease evaluation, and biomarker collection for research. A historical group of patients treated between 2013 and 2015 is used for comparison. Participants will be monitored for up to two years with evaluations of amputation rates, survival without amputation, general mortality, quality of life, disability, frailty, anxiety, and depression. Data collection includes clinical exams, questionnaires, imaging, and biomarker analysis. The study aims to improve understanding of outcomes and risk factors in SLI and supports long-term patient follow-up.

Leg Ischaemia Management Collaboration