Actively Recruiting
Lemborexant vs Zopiclone vs Clonidine for Insomnia Treatment in Chronic Pain Patients
Led by Salem Anaesthesia Pain Clinic · Updated on 2025-01-27
150
Participants Needed
1
Research Sites
161 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Prospective observational crossover study of 150 consenting adult patients who are undergoing chronic pain management. For insomnia treatment, each patient ingests prescribed doses of Lemborexant or Zopiclone or Clonidine on alternate nights. Each patient uses a special validated sleep diary to collect data including pain score, sleep score, sleep duration, sleep medication type, and adverse effects. Each patient completes the diary for 3 continuous weeks. Pain is measured using the numeric pain rating scale. Sleep score is measured using the Likert sleep scale. A change in the pain or sleep scores by 2-points is considered significant.
CONDITIONS
Official Title
Lemborexant vs Zopiclone vs Clonidine for Insomnia Treatment in Chronic Pain Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult chronic pain patients
- Good treatment compliance
- Severe chronic insomnia
- Failure of non-pharmacologic sleep therapy
- Regular Zopiclone therapy for 3 months or more
- Regular sleep diary use
- Regular pain diary use
- Informed consent for diary review
- Consent for clinical record quality assurance review
You will not qualify if you...
- Obstructive sleep apnea
- Body mass index (BMI) 40 or higher
- Organ insufficiency
- Cognitive disorder
- Inability to provide consent
- Major neuropsychiatric disorder
- Unreliable diary
- Cannabis use
- Regular alcohol intake
- Stimulant use
- Substance abuse
- Poor treatment compliance
- High dose opioid use
- Gabapentinoid use
- Sedative use
- Mild insomnia
- Irregular Zopiclone intake
- Regular Zopiclone therapy for less than 3 months
- Previous adverse or allergic reactions to Clonidine or Zopiclone
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Salem Anaesthesia Pain Clinic
Surrey, British Columbia, Canada, V3S 7J1
Actively Recruiting
Research Team
O
Olu Bamgbade, MD,FRCPC
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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