What this Trial Is About

This research aims to compare the safety and effectiveness of three medications—Lemborexant, Zopiclone, and Clonidine—for treating chronic insomnia in adults who also suffer from chronic pain. It involves 150 adult patients who are already managing chronic pain and experiencing severe insomnia that has not improved with non-drug sleep therapies. Participants have been regularly using Zopiclone for at least three months before joining the study. During the study, each participant takes prescribed doses of Lemborexant, Zopiclone, or Clonidine on alternating nights over a continuous period of three weeks. They keep a validated sleep diary to record their pain levels, sleep quality, sleep duration, type of sleep medication taken, and any side effects experienced. Pain is assessed using a numeric rating scale, while sleep quality is measured with the Likert sleep scale. Participants are closely monitored through their sleep and pain diaries, which provide detailed daily information. Researchers analyze changes in pain and sleep scores, considering a 2-point change as significant. The primary outcome is the objective sleep quality score measured over three weeks. Safety and adverse effects are also recorded to evaluate the medications' tolerability during the study period.

Lemborexant vs Zopiclone vs Clonidine for Insomnia Treatment in Chronic Pain Patients