Actively Recruiting
Leprosy Active Searching Trial in Brazil
Led by Hospital Alemão Oswaldo Cruz · Updated on 2026-04-28
1925
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to assess whether a multifactorial active case-finding strategy improves the detection of leprosy cases in Brazil compared to usual screening practices. The main questions it aims to answer are: \- Does the intervention increase the number of new leprosy cases detected compared to standard care? Participants will: * Receive community awareness about leprosy. * Be screened using the Leprosy Suspicion Questionnaire at priority areas identified by georeference tools. * Undergo clinical evaluation by a trained medical team. * If leprosy is diagnosed, affected patients will collect complementary laboratory exams Healthcare professionals from primary care units will receive training in leprosy, while researchers will monitor changes in leprosy incidence over a 12-month period using data from Brazil's national notification system. The study will provide insights into underdiagnosis and the clinical profiles of patients who have been diagnosed.
CONDITIONS
Official Title
Leprosy Active Searching Trial in Brazil
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Municipality recognized as part of the Brazilian Federation
- Municipality classified by the Ministry of Health as having leprosy cases from 2015 to 2019
- Municipality authorized by the government to participate in the study
- Primary Health Units with territorial coverage within participating municipalities
- Patients with positive Leprosy Suspicion Questionnaire
- Children under 5 with consent from parents or guardians
- Children 5-17 years old with parental consent and minor's assent
- Adults over 18 years old with informed consent for tests and clinical evaluation
You will not qualify if you...
- Municipalities with population size below 10th percentile or above 90th percentile
- Municipalities without leprosy cases from 2015 to 2019
- Municipalities recently involved (less than one year) in other active case-finding programs besides usual ones
- Primary Health Units missing key healthcare team members (physician, nurse, or community health agents)
- Primary Health Units with no land access (e.g., riverside populations)
- Primary Health Units serving exclusively indigenous populations
- Patients with negative Leprosy Suspicion Questionnaire
- Patients previously diagnosed or treated for leprosy
- Patients residing outside the selected municipality
AI-Screening
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Trial Site Locations
Total: 1 location
1
Hospital Alemão Oswaldo Cruz
São Paulo, Brazil, 01327-001
Actively Recruiting
Research Team
S
Sebastian A Vernal, MD, PhD
CONTACT
K
Katia C Braz
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
SCREENING
Number of Arms
2
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