Actively Recruiting
Leptin: A Marker for AML Chemo-Sensitivity
Led by Fujian Medical University Union Hospital · Updated on 2025-09-09
86
Participants Needed
1
Research Sites
73 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Acute Myeloid Leukemia (AML) is a malignant clonal disorder of hematopoietic stem/progenitor cells, with a five-year survival rate of approximately 30%. Chemotherapy resistance and relapse remain major challenges. Increased bone marrow adipocytes contribute to AML cell drug resistance.This study found that elevated levels of the adipokine leptin enhance oxidative phosphorylation (OXPHOS) in AML cells, accompanied by increased mitochondrial reactive oxygen species (mtROS), which stimulates antioxidant capacity and thereby induces chemotherapy resistance. By establishing a correlation between leptin levels in bone marrow supernatant and clinical outcomes in AML patients, this research provides novel strategic insights for targeting drug resistance and improving prognostic evaluation.
CONDITIONS
Official Title
Leptin: A Marker for AML Chemo-Sensitivity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis meets the "Chinese guidelines for diagnosis and treatment of adult acute myeloid leukemia (not APL) (2023)"
- First diagnosis of AML with no prior chemotherapy
- Participation with family support and signed informed consent documents
You will not qualify if you...
- Presence of other cancers requiring treatment
- Infectious diseases including SARS, viral hepatitis, or HIV/AIDS
- Major surgery within the last 21 days
- Performance Status score greater than 3
- Severe liver or kidney dysfunction or serious infection
- Severe psychiatric disorders affecting study understanding or voluntary withdrawal
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Fujian Medical University Union Hospital
Fuzhou, Fujian, China, 350001
Actively Recruiting
Research Team
H
Huifang Huang
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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