Actively Recruiting
Letrozole and Misoprostol for Early Pregnancy Loss Management
Led by University of Pennsylvania · Updated on 2025-08-05
30
Participants Needed
1
Research Sites
98 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A pilot cohort study to preliminarily investigate the efficacy of pretreatment with letrozole 10 mg daily for three consecutive days followed by treatment with misoprostol 800 mcg vaginally for medical management of early pregnancy loss in a US population. Patients will be followed to assess efficacy of this treatment regimen, as well as additional interventions needed, side effects, adverse events, and patient acceptability.
CONDITIONS
Official Title
Letrozole and Misoprostol for Early Pregnancy Loss Management
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to participate in the informed consent process and provide a signed and dated consent form
- Willing to comply with all study procedures and available for the study duration
- Access to a working mobile phone
- English-speaking
- Age 18 years or older
- Confirmed diagnosis of intrauterine embryonic/fetal demise or anembryonic gestation by ultrasound showing a fetal pole without cardiac activity measuring between 5.3 and 40 mm or abnormal growth pattern diagnostic of early pregnancy failure
You will not qualify if you...
- Incomplete or inevitable abortion
- Allergy or contraindication to letrozole or misoprostol
- Unable to return for clinic-based follow-up
- Twin or multiple pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
PEACE / Penn Medicine
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
A
Arden McAllister, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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