Actively Recruiting
Levetiracetam Three Times Daily in Epilepsy
Led by Waad Alkathiri · Updated on 2026-03-24
120
Participants Needed
1
Research Sites
169 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this clinical trial is to evaluate the efficacy and tolerability of Levetiracetam administered three times daily in patients with epilepsy. The primary objective is to investigate whether orally administered Levetiracetam three times daily dosing is superior in seizure-free days compared to standard twice-daily dosing in patients with epilepsy. Key questions include: * Does LEV improve seizure control, as measured by seizure-free days? * What adverse events or safety concerns are observed with LEV treatment? Participants will receive Levetiracetam administered three times daily during the treatment phase. The study will use a self-matched, pre-post design in which each participant serves as their own control. Baseline seizure activity and safety data will be collected prior to LEV initiation and compared with data obtained during the treatment period. Participants will attend scheduled clinic visits for efficacy and safety evaluations and will maintain a daily diary to record seizure frequency and any treatment-related events.
CONDITIONS
Official Title
Levetiracetam Three Times Daily in Epilepsy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or older
- Diagnosed with uncontrolled epilepsy of any type with one or more unprovoked seizures in the last 6 months
- Currently on Levetiracetam monotherapy
- Have been using Levetiracetam for at least 12 months prior to enrollment
- Taking high dose Levetiracetam (1.5 to 3 grams daily)
You will not qualify if you...
- Younger than 18 years
- Received intravenous Levetiracetam within the last 24 hours
- Using other antiepileptic drugs simultaneously
- Received other antiepileptic drugs in the last two weeks
- Pregnant women
- Renal impairment with creatinine clearance less than 30 or acute kidney injury
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
King Saud University
Riyadh, Riyadh Region, Saudi Arabia, 13321
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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