Actively Recruiting
Li-Fraumeni & TP53 (LiFT UP): Understanding and Progress
Led by Dana-Farber Cancer Institute · Updated on 2026-03-27
1500
Participants Needed
3
Research Sites
641 weeks
Total Duration
On this page
Sponsors
D
Dana-Farber Cancer Institute
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research study is to learn more about variants in the TP53 gene both associated with Li-Fraumeni Syndrome (LFS), a hereditary cancer risk condition, and TP53 variants found in the blood for other reasons (e.g. ACE/CHIP and mosaicism).
CONDITIONS
Official Title
Li-Fraumeni & TP53 (LiFT UP): Understanding and Progress
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals with a TP53 pathogenic or likely pathogenic variant identified in blood or saliva
- Individuals with variants of uncertain significance in TP53 may be eligible at the PI's discretion
- Blood relatives of individuals with a TP53 variant, who may be presumed obligate carriers or healthy controls
- Individuals who meet Classic or Chompret LFS criteria whether or not they have a TP53 gene variant
- Individuals may enroll their deceased relatives in the study
- Individuals with a known TP53 variant that is not LFS, but rather ACE, CHIP, or mosaicism
- Individuals participating in other LFS studies can still enroll in LiFT UP. Investigators may be collaborators
You will not qualify if you...
- Individuals who decline to sign consent
- Individuals who are unable to give consent or assent and are without a designated healthcare proxy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Boston Children's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
2
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02215
Actively Recruiting
3
Judy E. Garber
Boston, Massachusetts, United States, 02215
Actively Recruiting
Research Team
J
Judy E Garber, MD, MPH
CONTACT
S
Sophie Cahill, BS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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