Actively Recruiting
Lidocaine, Dexmedetomidine, Esmolol and Magnesium Effect on Optic Nerve Sheath Diameter After Laryngoscopy
Led by Haseki Training and Research Hospital · Updated on 2025-03-20
100
Participants Needed
1
Research Sites
71 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This clinical trial aims to compare the effects of lidocaine, dexmedetomidine, esmolol, and magnesium on optic nerve sheath diameter and hemodynamic response to laryngoscopy. The participants will be patients determined to need intubation and general anesthesia for any elective surgery. Each participant will receive either lidocaine, dexmedetomidine, esmolol, magnesium, or none before anesthesia induction, according to randomization. The investigator will measure the optic nerve sheath diameter by ultrasonography before and after intubation. Researchers will compare the difference between optic nerve sheath diameter, systolic blood pressure, and heart rate before and after laryngoscopy and search for the most stable group. The trial aims to determine a general anesthesia induction protocol for patients sensitive to intracranial pressure changes reflected as optic nerve sheath diameter for easy monitoring.
CONDITIONS
Official Title
Lidocaine, Dexmedetomidine, Esmolol and Magnesium Effect on Optic Nerve Sheath Diameter After Laryngoscopy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 to 80 years who will receive endotracheal intubation for general anesthesia
- Patients with American Society of Anesthesiologists (ASA) Physical Status classification I to III
You will not qualify if you...
- Allergy to dexmedetomidine, esmolol, lidocaine, or magnesium
- Uncontrolled hypertension or advanced heart failure with ejection fraction below 35%
- Cardiac arrhythmias, especially Type 2 and 3 blocks or supraventricular arrhythmias
- Renal failure with glomerular filtration rate below 30 or severe liver failure
- Known acute or previous intracranial pathology or diagnosis of epilepsy
- Predefined difficult airway examination
- More than one attempt required for intubation or laryngoscopy lasting more than 20 seconds
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Haseki Trainig and Research Hospital
Istanbul, Turkey (Türkiye)
Actively Recruiting
Research Team
B
Berna Caliskan, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
5
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