Actively Recruiting
Comparison of Lidocaine Alone Versus Lidocaine With Dexmedetomidine for Intravenous Regional Anesthesia in Upper Limb Surgery
Led by Fatima Memorial Hospital · Updated on 2025-06-24
90
Participants Needed
1
Research Sites
1 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the use of lidocaine alone versus lidocaine combined with dexmedetomidine for intravenous regional anesthesia (IVRA) in upper limb surgery. The study aims to compare these treatments in terms of pain levels and the duration of pain relief after surgery. IVRA involves using a pneumatic tourniquet and injecting a local anesthetic to numb the limb during surgeries lasting less than one hour. This technique has some limitations such as tourniquet pain and limited postoperative pain control, so this research explores whether adding dexmedetomidine can improve outcomes. The study compares two groups: one receiving 40 ml of 0.5% lidocaine alone, and the other receiving the same lidocaine dose combined with dexmedetomidine at 0.5 micrograms per kilogram. Dexmedetomidine is an alpha-2 adrenergic receptor agonist known for its sedative and pain-relieving effects. Participants will undergo intravenous regional anesthesia with these medications administered below the tourniquet, which isolates the limb for surgery. Participants will be monitored for pain relief duration up to 24 hours after surgery and pain scores measured by a visual analogue scale two hours post-operation. The study is randomized without blinding. Researchers will assess how long postoperative pain relief lasts and how intense the pain is during recovery. The trial involves elective surgeries lasting under 45 minutes and tracks outcomes to better understand how these medications work in this setting.
CONDITIONS
Brief Title
Lidocaine vs. Lidocaine With Dexmedetomidine for Intravenous Regional Anesthesia (IVRA) in Upper Limb Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- American Society of Anesthesiology Status I
- American Society of Anesthesiology Status II
- Elective surgery
- Surgery duration <45 minutes
You will not qualify if you...
- Sleep apnea
- Body mass index greater than 30
- Heart block
- Uncontrolled hypertension
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 45 minutes (duration of surgery)
Participants receive intravenous regional anesthesia with either lidocaine alone or lidocaine combined with dexmedetomidine during upper limb surgery lasting less than 45 minutes.
1 treatment visit (in-person)
Duration - Up to 24 hours post surgery
Participants are monitored for up to 24 hours after surgery to assess postoperative pain relief and pain levels.
1 follow-up visit approximately 2 hours post-operation
Trial Site Locations
Total: 1 location
1
Department of Anesthesiology, Fatima Memorial Hospital
Lahore, Punjab Province, Pakistan, 55000
Actively Recruiting
Research Team
M
Muhammad M Younas, MBBS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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