Protocol of a Nationwide Observational Cohort Study for Long-Term Impacts on Lung Health and Life after Tuberculosis in Korea (LIFE-TB).
Chiwook Chung, Jinsoo Min, Doosoo Jeon...
https://pubmed.ncbi.nlm.nih.gov/41088970Actively Recruiting
Age: 19Years +
All Genders
ID06946784
LIFE-TB Long-Term Impacts on Lung Health and Life After Tuberculosis in Korea
Led by Yonsei University · Updated on 2025-04-27
360
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
Researchers are conducting a nationwide observational study in Korea to understand the long-term effects of tuberculosis (TB) on lung health and quality of life. This study will include adults currently being treated for pulmonary TB or those who have completed treatment. The goal is to fill the knowledge gap about post-TB lung disease by tracking health outcomes over time. Participants will be enrolled from six medical centers and followed for five years. Data collected will include demographic details, TB history, comorbidities, medications, lung symptoms, chest imaging, lung function tests, and quality of life questionnaires. Clinical imaging such as chest CT scans will only be used if done as part of routine care. No additional interventions or study-specific treatments are required. During the study, participants will have annual visits with assessments including symptom scoring, chest X-rays, spirometry, and quality of life measures. Laboratory tests like blood work and infection screenings will be done at the start. Researchers will analyze respiratory symptoms, lung imaging abnormalities, lung function, and quality of life changes over the follow-up period to understand the progression of post-TB lung disease and factors linked to poorer outcomes.
CONDITIONS
Brief Title
LIFE-TB ; Long-Term Impacts on Lung Health and Life After Tuberculosis in Korea
Who Can Participate
Age: 19Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Age 19 years or older
- Diagnosed with pulmonary tuberculosis and either initiating or undergoing treatment or history of treated pulmonary tuberculosis
You will not qualify if you...
- Age under 19 years
- Extrapulmonary tuberculosis without lung involvement
- Refusal to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Monitoring
Duration - Up to 6 years
Participants are observed to assess respiratory symptoms, radiographic findings, pulmonary function, and quality of life related to their tuberculosis history.
Annual visits with additional assessments at 6 months
Trial Site Locations
Total: 1 location
1
Department of Internal Medicine, Yonsei University College of Medicine Division of Pulmonology, Severance Hospital, Yonsei University Health System
Seoul, South Korea
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How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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