Actively Recruiting
Lifestyle for the BRAin Health - Nutrition and Exercise Training Intervention
Led by Slovak Academy of Sciences · Updated on 2025-05-29
40
Participants Needed
1
Research Sites
117 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Due to the increasing incidence of dementia and the lack of causal treatment, non-pharmacological interventions represent an attractive and effective therapeutic strategy of neurodegenerative diseases, such as Alzheimer's disease. The aim of the study is to assess the impact of a supervised 9-month intervention with aerobic-strength training and nutritional counseling compared to cognitive training and stretching on the brain, cognitive and motor functions, metabolism, physical fitnes and plasma markers of neurodegenertion in older adults at increased risk of developing Alzheimer's disease.
CONDITIONS
Official Title
Lifestyle for the BRAin Health - Nutrition and Exercise Training Intervention
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Non-smokers
- Signed informed consent
- Presence of subjective or mild cognitive impairment (SCI/aMCI)
- Elevated levels of selected biomarkers confirming the presence of a pathological process characteristic of Alzheimer's disease
- Absence of any psychological, sociological, or geographical factors that could jeopardize participation in the project.
You will not qualify if you...
- Presence of severe cardiovascular, liver, or kidney diseases; advanced or poorly controlled diabetes mellitus (HbA1c >7%), treated with insulin or incretin analogs; cancer or any other severe disease as assessed by the responsible physician
- History of cancer treated with chemotherapy or radiotherapy if within less than 5 years post-treatment
- Lack of cooperation, inflexible schedule, or problematic transportation
- Insufficient functional capacity or presence of comorbidities that prevent participation in the training program (as assessed by relevant specialists)
- Presence of a pacemaker or any metal implants (contraindication for MRI examination), or allergy to local anesthetics (contraindication for muscle biopsy)
- Smoking, alcohol dependence, or addiction to other narcotic substances
- Stroke or myocardial infarction within the last year
- Long-term treatment for psychiatric disorders (except compensated depressive syndrome)
- Other diseases of the musculoskeletal or nervous system that interfere with exercise or cognition such as severe arthritis, Parkinson's disease, significant essential tremor, epilepsy
- Concurrent participation in another clinical study
- Therapy with cholinesterase inhibitors unless the patient is on a stable dose
AI-Screening
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Trial Site Locations
Total: 1 location
1
Biomedical Research Center Slovak Academy of Sciences
Bratislava, Bratislava Region, Slovakia, 84505
Actively Recruiting
Research Team
B
Barbora Ukropcova, Prof.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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