Effects of Mindfulness Yoga, Time-Restricted Eating, and Cognitive Training on Brain Health in Older Adults at Risk for Alzheimers Disease

What this Trial Is About

Researchers are studying the effects of a 9-month lifestyle intervention on older adults aged 60 to 80 who are at increased risk of developing Alzheimers disease. The trial compares two groups one combining yoga-based mindfulness techniques with time-restricted eating, and the other receiving cognitive training with stretching. The goal is to assess changes in cognitive function, plasma markers of neurodegeneration such as tau protein, physical fitness, and metabolism. Participants in the first group will attend twice-weekly 90-minute sessions of yoga, including physical postures, breathing exercises, and meditation, alongside following a time-restricted eating schedule with nutritional counseling promoting a flexitarian diet. The second group will engage in twice-weekly 90-minute sessions of cognitive training targeting memory, attention, executive function, and social skills, paired with guided stretching exercises led by therapists. Both interventions last for nine months and are designed to evaluate different approaches to brain health. During the study, participants will have their cognitive function and plasma biomarkers measured at the start and end of the nine months. Additional assessments include computerized cognitive tests, depression and anxiety scales, adherence monitoring, and quality of life questionnaires. This comprehensive evaluation allows researchers to understand the impact of these lifestyle interventions on brain health and overall well-being in older adults at risk of Alzheimers disease.

Lifestyle for the BRAin Health - Time Restricted Eating and Mindfulness