Actively Recruiting
Lifestyle for the BRAin Health - Time Restricted Eating and Mindfulness
Led by St. Anne's University Hospital Brno, Czech Republic · Updated on 2025-06-27
48
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
S
St. Anne's University Hospital Brno, Czech Republic
Lead Sponsor
S
Slovak Academy of Sciences
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying the effects of a 9-month lifestyle intervention on older adults aged 60 to 80 who are at increased risk of developing Alzheimer's disease. The trial compares two groups: one combining yoga-based mindfulness techniques with time-restricted eating, and the other receiving cognitive training with stretching. The goal is to assess changes in cognitive function, plasma markers of neurodegeneration such as tau protein, physical fitness, and metabolism. Participants in the first group will attend twice-weekly 90-minute sessions of yoga, including physical postures, breathing exercises, and meditation, alongside following a time-restricted eating schedule with nutritional counseling promoting a flexitarian diet. The second group will engage in twice-weekly 90-minute sessions of cognitive training targeting memory, attention, executive function, and social skills, paired with guided stretching exercises led by therapists. Both interventions last for nine months and are designed to evaluate different approaches to brain health. During the study, participants will have their cognitive function and plasma biomarkers measured at the start and end of the nine months. Additional assessments include computerized cognitive tests, depression and anxiety scales, adherence monitoring, and quality of life questionnaires. This comprehensive evaluation allows researchers to understand the impact of these lifestyle interventions on brain health and overall well-being in older adults at risk of Alzheimer's disease.
CONDITIONS
Brief Title
Lifestyle for the BRAin Health - Time Restricted Eating and Mindfulness
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 60 to 80 years
- Diagnosis of Subjective Cognitive Impairment (SCI) or Mild Cognitive Impairment (MCI)
- Mini-mental-scale (MMSE) score between 24 and 30
- Positive plasma pTau217 biomarker
- Stable dose of iAChE therapy if applicable
- Ability to participate in a 9-month intervention
You will not qualify if you...
- Stroke or myocardial infarction within the past year
- Decompensated internal conditions such as severe heart failure, kidney failure, unstable diabetes, or GLP1 agonist therapy
- Long-term psychiatric treatment except well-managed depression
- Neurological conditions affecting mobility or cognition like Parkinson's disease, severe tremor, or epilepsy
- Severe sensory or motor impairment preventing participation
- Active cancer treated within the past 5 years
- Poor anticipated compliance due to transport, time constraints, or non-cooperation
- Concurrent participation in another clinical study
- Unstable iAChE medication regimen
- Substance or alcohol dependence
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 9 months
Participants engage in a 9-month intervention consisting of either yoga-based mindfulness sessions combined with time-restricted eating, or cognitive training combined with guided stretching. Sessions occur twice weekly for 90 minutes each, focusing on improving cognitive function, physical fitness, and metabolic health.
Twice-weekly sessions for 9 months
Trial Site Locations
Total: 1 location
1
Fnusa/ Icrc
Brno, Czechia, 64400
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here