Actively Recruiting
Light Stimulation to Improve Visual Function After Optic Neuritis in Persons with Multiple Sclerosis
Led by Technical University of Munich · Updated on 2024-11-22
50
Participants Needed
1
Research Sites
126 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this monocentric randomized controlled intervention study is to improve visual function in persons with multiple sclerosis following optic neuritis (neuritis nervi optici) by means of a light stimulation. In the treatment arm, two 80-second light stimulations are to be administered daily for 12 days in 25 persons with multiple sclerosis following recent optic neuritis (1-3 months). For the standardized application of light stimulation in the sense of standardized training, the light stimulation is to be carried out by watching a generated flicker video on a mobile phone. In a sham-intervened control group (sample size 25), the spontaneous course after optic neuritis will be recorded in parallel. Intensive neuronal stimulation of the visual pathway will be used to stimulate regenerative processes, which will be recorded by means of changes in high-contrast visual acuity (primary endpoint). Secondary endpoints are changes in a colored-contrast test, in 2.5% low contrast visual acuity, the peak conduction latency of visual evoked potentials, and retinal layer thicknesses and vessel densities measured in optical coherence tomography and optical coherence tomorgraphic angiography. These physiological parameters should help to understand the underlying processes of a potentially altered visual performance.
CONDITIONS
Official Title
Light Stimulation to Improve Visual Function After Optic Neuritis in Persons with Multiple Sclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with relapsing remitting multiple sclerosis, clinically isolated syndrome, or no indication of chronic inflammatory central nervous system disease
- Aged between 18 and 60 years
- Experienced optic neuritis within the past 1 to 3 months
You will not qualify if you...
- History of epilepsy
- Experience of light-triggered migraines
- Insufficient vision correction
- Presence of retinal diseases such as glaucoma, macular edema, or macular degeneration
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Technical University of Munich
Munich, Bavaria, Germany, 81675
Actively Recruiting
Research Team
P
Philipp Gulde Gulde, Dr. phil.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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