Actively Recruiting
Light Stimulation to Improve Visual Function After Optic Neuritis in Persons with Multiple Sclerosis
Led by Technical University of Munich · Updated on 2024-11-22
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating a light stimulation treatment to improve visual function in people with multiple sclerosis who have recently experienced optic neuritis. This randomized controlled study aims to understand how intense visual stimulation might help regenerate the visual system. The study compares the effects of light stimulation with a control group receiving sham treatment to observe natural recovery progress. Participants in the treatment group will watch a flickering video on a mobile phone twice daily for 80 seconds each session, over 12 days. The control group will view a white screen for the same duration and frequency. This standardized light exposure is designed to stimulate the visual pathway and promote recovery after optic neuritis. Throughout the study, participants will undergo tests of visual sensitivity, including high and low contrast measures, and visual evoked potentials. Imaging tests like optical coherence tomography and angiography will track retinal layers and vessel density. These assessments occur before treatment, immediately after the first session, after 12 days of training, and 22 days post-treatment to monitor lasting effects and safety. Total participation spans several weeks to capture recovery progress.
CONDITIONS
Brief Title
Light Stimulation to Improve Visual Function After Optic Neuritis in Persons with Multiple Sclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Relapsing remitting multiple sclerosis or clinically isolated syndrome or no indication of chronic inflammatory central nervous system disease
- Age 18 to 60 years
- Optic neuritis within 1 to 3 months
You will not qualify if you...
- Epilepsy
- Light-triggered migraine
- Insufficient vision correction
- Retinal disease such as glaucoma, macular edema, or macular degeneration
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 12 days
Participants receive light stimulation or sham light stimulation using a device twice a day for 12 days.
Daily sessions twice a day for 12 days
Duration - 10 days
Participants are monitored for retention of visual function improvements after the intervention ends.
Visits at 1 day and 10 days post-intervention
Trial Site Locations
Total: 1 location
1
Technical University of Munich
Munich, Bavaria, Germany, 81675
Actively Recruiting
Research Team
P
Philipp Gulde Gulde, Dr. phil.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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