Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
ID05519878

Assessing Effectiveness of Light Therapy and Occupational Therapy for Fatigue Management in Patients With Genitourinary Cancers

Led by City of Hope Medical Center ยท Updated on 2025-12-24

224

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

Sponsors

C

City of Hope Medical Center

Lead Sponsor

N

National Cancer Institute (NCI)

Collaborating Sponsor

AI-Summary

What this Trial Is About

This research aims to evaluate the effects of light therapy and occupational therapy in managing cancer-related fatigue (CRF) in patients with genitourinary cancers such as prostate, kidney, and bladder cancer. The study explores whether combining these two approaches can improve fatigue, offering a low burden and accessible intervention to support cancer patients. Occupational therapy is commonly used but often underutilized in cancer care, and this study seeks to assess its added benefit alongside light therapy. Participants are randomly assigned to one of four groups: one group uses bright white light therapy glasses for 30 minutes every morning for three months with follow-up sessions, another group receives six one-hour occupational therapy sessions, a third group receives both light therapy and occupational therapy, and the fourth group receives routine treatment and follow-up care with their oncologist. After these interventions, patients are followed for an additional three months to monitor outcomes. Throughout the study, participants complete questionnaires assessing fatigue levels and occupational performance at baseline, six weeks, and three months. Researchers monitor fatigue using the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue tool and evaluate occupational performance with the Canadian Occupational and Performance Measure (COPM). Safety and adherence are supported by follow-up visits, and the total participation duration is approximately six months from baseline through follow-up.

CONDITIONS

Brief Title

Light Therapy and Occupational Therapy Fatigue Management-Based Intervention for Patients With Genitourinary Cancers

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Aged 18 and over
  • Fluent in English
  • Receiving active systemic therapy or radiotherapy
  • Diagnosed with genitourinary cancer (prostate, kidney, bladder)
  • Physician-assessed grade 1 or 2 fatigue at study entry
  • Prognosis of at least six months
  • Able and willing to provide informed consent
  • Pre-screen fatigue score (FACIT-Fatigue) of 30 or less
Not Eligible

You will not qualify if you...

  • Severe sleep disorders such as narcolepsy
  • Eye diseases limiting light processing (e.g., untreated cataracts, severe glaucoma, macular degeneration, blindness, retinal disorders)
  • Severe psychological impairment (e.g., bipolar disorder, manic episodes)
  • Currently working night shifts
  • Prior use of light therapy for fatigue or depression
  • Secondary cancer diagnosis within past 5 years
  • Plans to travel across time zones during treatment
  • Pregnancy
  • Recent eye surgery causing irritation within past 6 months
  • Sensitivity to light, epilepsy, or history of seizures

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - 3 months

Participants receive one of the study interventions: bright white light therapy using light glasses daily for 3 months, occupational therapy with 6 sessions, a combination of both, or routine treatment and usual care.

6 follow-up visits depending on intervention group

Follow-up

Duration - 3 months

Participants are monitored for 3 months after completing the intervention to assess fatigue and occupational performance.

Visits as part of routine follow-up care

Trial Site Locations

Total: 1 location

1

City of Hope Medical Center

Duarte, California, United States, 91010

Actively Recruiting

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How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

FACTORIAL

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

4

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