International Parkinson and movement disorder society evidence-based medicine review: Update on treatments for the motor symptoms of Parkinson's disease.
Susan H Fox, Regina Katzenschlager, Shen-Yang Lim...
https://pubmed.ncbi.nlm.nih.gov/29570866Actively Recruiting
Phase Not Applicable
Age: 50Years - 80Years
All Genders
ID06129942
Light Therapy in Parkinson's Disease: a Prospective, Observational Study
Led by Second Affiliated Hospital of Soochow University · Updated on 2025-02-12
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of bright light therapy on motor symptoms and sleep disorders in patients with Parkinson's disease. This randomized controlled trial aims to clarify how bright light affects these symptoms and explore the possible mechanisms behind these effects. Previous studies have shown benefits of light therapy on sleep quality, mood, anxiety, and motor function in Parkinson's disease, but these findings have not been reported in Chinese patients. Participants will be randomly assigned to one of two groups: one group receives bright light therapy with a device emitting 10,000 lux, and the other group receives a placebo device emitting 300 lux. Both groups will use their respective light boxes for one hour twice daily—once in the morning between 8:00 and 11:00 and once in the afternoon between 17:00 and 19:00—over the course of one month. Participants are instructed to stay awake and move under the light source during treatment. Throughout the study, participants will undergo multiple assessments at baseline and at 4, 8, and 12 weeks to monitor sleep quality through polysomnography and various clinical scales measuring motor and non-motor symptoms of Parkinson's disease. Researchers will also evaluate brain activity, hormone levels, anxiety, depression, cognition, and quality of life. Safety and effects will be closely monitored during these visits, with the total study duration lasting up to 12 weeks.
CONDITIONS
Brief Title
Light Therapy in Parkinson's Disease
Who Can Participate
Age: 50Years - 80Years
All Genders
Eligibility Criteria
You may qualify if you...
- Diagnosed with Parkinson's disease according to MDS criteria
- Clinical symptoms consistent with Hoehn and Yahr stages 2-3
- Stable drug treatment for at least one month
- Signed informed consent and agreed not to change medications during the study period
You will not qualify if you...
- Using hypnotic or stimulating drugs
- Using antidepressants unless stable for more than three months
- Visual impairments such as cataract, glaucoma, or blindness
- Cognitive impairment with MMSE score below 24
- Uncontrollable hallucinations or mental illnesses
- Presence of sleep phase delay/advance syndrome, shift work, or jet lag
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Implementation
Duration - 1 month
Participants receive light therapy using devices with different light intensities for 1 hour twice daily in the morning and afternoon over a period of one month.
4 visits (baseline and at 4, 8, and 12 weeks)
Trial Site Locations
Total: 1 location
1
Department of Neurology, Second Affiliated Hospital of Soochow University
Suzhou, Jiangsu, China, 215004
Actively Recruiting
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Research Team
C
Chun-Feng Liu, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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