Actively Recruiting
Role of Topical Application of Lignocaine Versus 0.2% Glyceryl Trinitrate (GTN) Ointment as a Postoperative Local Analgesic in Hemorrhoidectomy in Terms of Pain Score, Wound Healing Time and Patient Satisfaction Level
Led by King Edward Medical University · Updated on 2025-09-08
64
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to compare the effectiveness of topical lignocaine ointment versus 0.2% glyceryl trinitrate (GTN) ointment for reducing postoperative pain and promoting wound healing in patients undergoing hemorrhoidectomy. Hemorrhoids are swollen veins in the anal area, and pain after surgery can delay recovery and affect comfort. The study focuses on determining which ointment provides better pain relief and wound healing outcomes following hemorrhoid removal surgery. Patients undergoing hemorrhoidectomy will be randomly assigned to one of two groups. One group will receive lignocaine ointment applied locally to the anal wound three times daily after surgery, while the other group will receive 0.2% GTN ointment on the same schedule. Both groups will receive standard postoperative care including sitz baths, stool softeners, and paracetamol for pain relief. The study will follow participants for 3 to 6 months overall, with treatment and monitoring focused on the first month after surgery. Participants will have their pain levels assessed using a visual analog scale (VAS) at various times after surgery, including 6, 12, 24, 48, and 72 hours, as well as at 7, 14, 21, and 28 days. Wound healing time will be tracked up to one month, and patient satisfaction will be measured at 6 weeks using a 5-point scale. Additional monitoring includes recording the time to first analgesic request, analgesia amounts, and any side effects such as wound secretion, itching, bleeding, or headaches. Data will be analyzed to compare outcomes between the two ointments.
CONDITIONS
Brief Title
"Lignocaine vs GTN Ointment for Postoperative Pain After Hemorrhoidectomy")
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 - 60 years
- Both genders
- Grade III and IV hemorrhoids diagnosed by consultant surgeon
- ASA grades I and II
You will not qualify if you...
- Allergy or reaction to lignocaine or GTN
- Pregnancy or lactation
- Concomitant perianal pathology needing surgery
- Cardiovascular disease
- Taking nitrates or calcium channel blockers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 month
Participants undergo hemorrhoidectomy surgery followed by topical application of either lignocaine or 0.2% glyceryl trinitrate ointment three times daily to manage postoperative pain and promote wound healing.
Multiple visits for pain assessment at 6, 12, 24, 48, 72 hours and Days 7, 14, 21, and 28 post-surgery
Duration - 6 weeks
Participants are followed for 6 weeks post-surgery to assess patient satisfaction, wound healing progress, and any side effects.
Visits for wound healing and satisfaction assessment after treatment completion
Trial Site Locations
Total: 1 location
1
King Edward Medical uUniveristy Mayo Hospital
Lahore, Punjab Province, Pakistan, 54000
Actively Recruiting
Research Team
H
Hafiz Ahmad Rauf, Mbbs,Fcps
K
KEMU/ Mayo Hospital lahore
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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