Comparing Limited and Extended Lymph Node Removal During Radical Prostatectomy for Localized or Locally Advanced Prostate Cancer

What this Trial Is About

Researchers are evaluating the effects of different extents of lymph node dissection performed alongside radical prostatectomy in men with localized or locally advanced prostate cancer. This randomized controlled study aims to compare outcomes between limited or no lymph node removal and extended lymph node removal during surgery. The goal is to optimize the volume of lymph node removal in these patients to better understand its impact on long-term survival and complications. Participants will be randomly assigned to receive either radical prostatectomy with limited or no lymph node dissection or radical prostatectomy with extended lymph node dissection. The extent of lymph node removal depends on the patients prostate cancer risk category, with extended dissection including more lymph nodes for higher-risk patients. The study tracks surgical details such as blood loss and surgery duration, as well as postoperative complications and length of hospital stay. During the study, participants will be followed for up to 5 to 7 years after surgery. Researchers will monitor metastasis-free survival as the primary outcome, along with secondary outcomes including biochemical recurrence-free survival, prostate cancer-specific survival, overall survival, and perioperative events. Follow-up visits will assess recovery, complications, and hospital stay length. The study involves careful evaluation of long-term cancer outcomes and surgical safety in men undergoing radical prostatectomy.

Limited Versus Extended Lymph Node Dissection During Radical Prostatectomy in Patients With Localized or Locally Advanced Prostate Cancer