Actively Recruiting
Linaclotide for Colonoscopy Bowel Prep
Led by University of Florida · Updated on 2026-01-23
10
Participants Needed
1
Research Sites
34 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if drug Linaclotide can be used as a single agent regimen to adequately prepare bowel for colonoscopy. The main question it aims to answer is: Does drug Linaclotide with Gatorade provide adequate bowel preparation for colonoscopy instead of the standard 4 Liters of Polyethylene glycol (PEG)? Participants will: Take one 290mg dose of Linaclotide 36 hours before the procedure and One 290mg dose of Linaclotide 8 hours before the procedure + 2 Liters of Gatorade and a clear liquid diet 24 hours before the procedure. As per standard of care, all patients will be made Nil Per Oral (NPO) starting midnight before the procedure. The colonoscopy report will then be reviewed for Boston Bowel Preparation Score (BBPS) as a marker of bowel preparation quality, insertion time as a marker of procedure difficulty as well as noted pathology and any complications or physician noted comments.
CONDITIONS
Official Title
Linaclotide for Colonoscopy Bowel Prep
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult male and female patients aged 18 to 65 years
- Scheduled for a colonoscopy during their hospital admission
You will not qualify if you...
- Pregnant patients
- Patients weighing less than 116 pounds
- Patients with prior colon resection surgeries
- Presence of colostomy
- Patients undergoing sigmoidoscopy or pouchoscopy
- Patients unable to swallow pills or tablets
- Patients using G or J feeding tubes for medications or preparation
- Patients unable to consent for themselves
- Patients with a history of renal failure
- Patients already taking Linaclotide
- Patients with past hypersensitivity reactions to Linaclotide
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UF Health
Gainesville, Florida, United States, 32608
Actively Recruiting
Research Team
P
Pavel Mazirka, MD
CONTACT
O
Oluwayemisi Ojewale, MD, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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