Actively Recruiting
Linezolid Plus Standard of Care
Led by University Hospital, Basel, Switzerland · Updated on 2026-03-24
606
Participants Needed
12
Research Sites
155 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Basel, Switzerland
Lead Sponsor
S
Swiss National Science Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of the study is to assess whether targeting virulence factors by administering linezolid in addition to standard antibiotic treatment improves outcomes in patients with Staphylococcus aureus bacteraemia.
CONDITIONS
Official Title
Linezolid Plus Standard of Care
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Staphylococcus aureus grown from at least one blood culture
- Hospitalized at a participating center
- 18 years or older
- Provided written informed consent or meet emergency exception criteria
You will not qualify if you...
- Initial drug treatment cannot start within 72 hours after the first positive blood culture
- History of positive S. aureus blood cultures between 72 hours and 180 days before screening
- Necrotising fasciitis
- Currently receiving linezolid or clindamycin
- Use of monoamine oxidase A or B inhibitors in the last two weeks
- Known allergy to linezolid or study drug ingredients
- Severe thrombocytopenia (platelet count below 30 x 10^9/L)
- Unable to take study drug by mouth or feeding tube
- Currently breastfeeding
- Local team believes death is imminent and unavoidable
- Receiving end-of-life care and antibiotics deemed inappropriate
- Local team believes study participation is not in patient's best interest
- Patient unwilling to participate or has an advance directive refusing participation
AI-Screening
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Trial Site Locations
Total: 12 locations
1
Kantonsspital Aarau (KSA)
Aarau, Canton of Aargau, Switzerland
Actively Recruiting
2
St. Claraspital
Basel, Canton of Basel-City, Switzerland
Actively Recruiting
3
Hôpitaux universitaires de Genève (HUG)
Geneva, Canton of Geneva, Switzerland
Not Yet Recruiting
4
Hôpital du Jura
Delémont, Canton of Jura, Switzerland
Not Yet Recruiting
5
Centre hospitalier universitaire vaudois (CHUV)
Lausanne, Canton of Vaud, Switzerland
Not Yet Recruiting
6
Kantonsspital Winterthur (KSW)
Winterthur, Canton of Zurich, Switzerland
Not Yet Recruiting
7
Ente Ospedaliero Cantonale (EOC)
Lugano, Canton Ticino, Switzerland
Actively Recruiting
8
University Hospital Basel (USB)
Basel, Switzerland, 4031
Actively Recruiting
9
Inselspital Bern
Bern, Switzerland
Not Yet Recruiting
10
HOCH Health Ostschweiz, Kantonsspital St.Gallen
Sankt Gallen, Switzerland
Not Yet Recruiting
11
Stadtspital Zürich Triemli
Zurich, Switzerland
Actively Recruiting
12
Universitätsspital Zürich (USZ)
Zurich, Switzerland
Actively Recruiting
Research Team
R
Richard Kühl, PD Dr. med.
CONTACT
N
Natalie Rose, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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