Actively Recruiting
Linking Affective Dynamics in Response to Daily Stress to Peripheral Vascular Function in Working Age Adults
Led by University of Delaware · Updated on 2025-09-17
18
Participants Needed
1
Research Sites
360 weeks
Total Duration
On this page
Sponsors
U
University of Delaware
Lead Sponsor
N
National Institute of General Medical Sciences (NIGMS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objective of this proposal is to determine whether heightened negative affective responsivity (NA-R) to daily stressors is related to blunted nitric oxide (NO)-mediated endothelium-dependent dilation (EDD) in working age adults and the extent to which this association is impacted by major depressive disorder (MDD).
CONDITIONS
Official Title
Linking Affective Dynamics in Response to Daily Stress to Peripheral Vascular Function in Working Age Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females aged 18 to 55 years
- Healthy adults with no current or past major psychiatric illness confirmed by clinical assessment
- Adults with major depressive disorder meeting DSM-5 criteria and currently symptomatic, including those with co-morbid anxiety, stress, or trauma-related disorders
- No unstable or chronic clinical diseases including cardiovascular, metabolic, renal, hepatic, autonomic, autoimmune, or dermatological conditions, confirmed by history, physical exam, and tests
- Adults with controlled elevated blood pressure (<130 mmHg), low-density lipoprotein (<160 mg/dl), and glucose (HbA1c <5.7%) allowed
- Sufficient English understanding to provide consent and comply with study procedures
- Willingness and ability to attend all study visits and follow the protocol
You will not qualify if you...
- Under 18 or over 55 years of age
- Lifetime or current co-morbid neuropsychiatric diseases such as bipolar disorder, psychosis, schizophrenia, eating disorders, OCD, or substance use disorders
- Serious active suicidal or homicidal thoughts with intent or plans
- Diagnosed chronic diseases including cardiovascular, metabolic, renal, hepatic, autonomic, autoimmune, or dermatological diseases based on medical history and clinical tests
- Resting systolic blood pressure ≥130 mmHg or body mass index ≥35 kg/m2
- Abnormal blood chemistries (LDL ≥160 mg/dl, HbA1c ≥5.7%) or abnormal ECG findings
- Use of medications affecting cardiovascular or psychoactive function within last 8 weeks
- Tobacco use including electronic cigarettes
- Pregnant, breastfeeding, or planning pregnancy; females of childbearing potential must have negative pregnancy tests during visits
- Current or past hormone replacement therapy use
- Allergy to study drugs or pharmacological agents
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Delaware
Newark, Delaware, United States, 19713
Actively Recruiting
Research Team
J
Jody Greaney, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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