Actively Recruiting
Links Between Self-awareness and Sociocognitive Processes in Neurodegenerative Diseases
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2026-04-15
34
Participants Needed
1
Research Sites
87 weeks
Total Duration
On this page
Sponsors
A
Assistance Publique - Hôpitaux de Paris
Lead Sponsor
I
Institut de psychologie
Collaborating Sponsor
AI-Summary
What this Trial Is About
This monocentric, non-interventional study (SELFSOC) investigates the relationship between self-awareness and social cognition in patients with behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD). The primary objective is to assess metacognitive efficiency related to social cognitive performance using a computerized facial emotion recognition task combined with confidence judgments. Metacognitive indices (including Mratio) will quantify the correspondence between subjective and objective performance. Thirty-four participants (17 bvFTD, 17 AD; age 50-80; MMSE ≥20) will complete two study visits involving tasks assessing emotion recognition, theory of mind, and memory.
CONDITIONS
Official Title
Links Between Self-awareness and Sociocognitive Processes in Neurodegenerative Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of possible or probable behavioral variant frontotemporal dementia according to the Rascovsky 2011 criteria OR diagnosis of Alzheimer's disease according to the Jack 2018 criteria, including biomarkers
- Mini-Mental State Examination (MMSE) score of 20 or higher
- Age between 50 and 80 years
- Sufficient reading and writing proficiency in French to complete study procedures, as judged by investigator
You will not qualify if you...
- Moderate to severe language disorders with confrontation naming score 32 or lower on DO 40 scale
- Inability to perform computerized tasks, as judged by investigator
- Presence of other neurological disorders including epilepsy, Lewy body disease, or vascular dementia
- Psychiatric conditions such as bipolar disorder, schizophrenia, or current major depressive episode
- Uncorrected visual impairment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Cognitive Neurology Center, Lariboisière-Fernand Widal Hospital Group, APHP
Paris, France, 75010
Actively Recruiting
Research Team
E
Emmanuel Cognat, MD PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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