Actively Recruiting
Lipopolysaccharide Adsorption (Efferon LPS NEO) in Children With Thermal Burns
Led by Efferon JSC · Updated on 2025-11-25
30
Participants Needed
2
Research Sites
78 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This observational pilot study aims to identify criteria for evaluating the effectiveness of hemoadsorption with the Efferon LPS NEO device in pediatric burn injury. Participants will be prospectively assigned to the treatment group and compared with a retrospectively selected control group. Each patient in the treatment group will undergo two hemoadsorption sessions, each lasting 6-12 hours, with an interval of 24-120 hours between procedures. The sessions may be performed in combination with hemofiltration or hemodiafiltration at the discretion of the investigator.
CONDITIONS
Official Title
Lipopolysaccharide Adsorption (Efferon LPS NEO) in Children With Thermal Burns
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Thermal burns of degree I and II with a lesion area of 40% or more (ICD-10: T20-T25, T29)
- Frank index greater than 90, indicating severe burn depth and area
- Hemoadsorption treatment started no later than 5 days after ICU admission
- Adequate infusion therapy of at least 30 mL/kg from study inclusion until first sorption
- Patient's condition allows for at least 6 hours of Efferon LPS NEO therapy
You will not qualify if you...
- Presence of end-stage renal disease
- Acute pulmonary embolism confirmed by CT scan
- Uncontrolled bleeding with acute blood loss within the last 24 hours
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Children's City Clinical Hospital No. 9 named after G.N. Speransky of the Moscow City Health Department
Moscow, Russia, 123317
Actively Recruiting
2
Children's municipal multi-specialty clinical center of high medical technology
Saint Petersburg, Russia
Actively Recruiting
Research Team
A
Alexandr Shelehov-Kravchenko, PhD, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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