Actively Recruiting
Lipopolysaccharide Adsorption (Efferon LPS) in Patients With Thermal Burns
Led by Efferon JSC · Updated on 2026-01-22
15
Participants Needed
1
Research Sites
120 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This observational pilot study aims to establish criteria for evaluating the effectiveness of hemoadsorption with the Efferon LPS device in adult patients with burn injury. Participants will be prospectively enrolled into the treatment group and compared with a retrospectively selected control group. Each patient in the treatment group will undergo two hemoadsorption sessions, each lasting 6-12 hours, with a 24 hours interval between sessions. The procedures may be performed in combination with hemofiltration or hemodiafiltration at the investigator's discretion.
CONDITIONS
Official Title
Lipopolysaccharide Adsorption (Efferon LPS) in Patients With Thermal Burns
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 65 years
- Thermal burn of severity I and II with lesion area of 40% or more (ICD-10: T20-T25, T29)
- Burn disease in the stage of acute toxemia or septicemia
- Frank Index equal or greater than 90
- Patient's condition allows for at least 6 hours of Efferon LPS therapy
You will not qualify if you...
- Isolated thermal inhalation injury
- Charlson Comorbidity Index greater than 8
- Dementia
- End-stage renal failure
- Acute pulmonary embolism confirmed by CT
- Acute myocardial infarction within the past 4 weeks
- Acute cerebrovascular accident
- Uncontrolled bleeding within the past 24 hours
- Any other condition making the patient unsuitable according to the investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
State Novosibirsk Regional Clinical Hospital
Novosibirsk, Russia, 630087
Actively Recruiting
Research Team
A
Alexandr Shelehov-Kravchenko, PhD, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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