Actively Recruiting
Lipoprotein Kinetics in T1D
Led by University of Missouri-Columbia · Updated on 2026-02-10
30
Participants Needed
1
Research Sites
294 weeks
Total Duration
On this page
Sponsors
U
University of Missouri-Columbia
Lead Sponsor
U
University of Washington
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research study is to understand how type 1 diabetes (T1D) increases the risk for cardiovascular diseases (heart attack and stroke). To this end, the investigators will compare apolipoprotein and triglyceride kinetics in people wtih T1D and healthy control participants.
CONDITIONS
Official Title
Lipoprotein Kinetics in T1D
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 45 years
- Premenopausal or eumenorrheic and not pregnant or breastfeeding
- Non-obese with body mass index between 18.5 and less than 30.0 kg/m2
- Fasting plasma triglyceride less than 150 mg/dL
- For control subjects: fasting plasma glucose less than 100 mg/dL
- For control subjects: plasma glucose less than 140 mg/dL 2 hours after 75 g oral glucose challenge
- For control subjects: HbA1c less than 5.6%
- For subjects with type 1 diabetes: stable insulin regimen (multiple daily injections or continuous subcutaneous insulin) for at least 8 weeks before screening
- For subjects with type 1 diabetes: no use of diabetes medications other than insulin
- For subjects with type 1 diabetes: HbA1c less than 8.0%, basal (overnight fasted)
- For subjects with type 1 diabetes: no severe symptomatic hypoglycemic events requiring assistance or medical facility in the last 6 months
You will not qualify if you...
- More than 1.5 hours of structured exercise per week
- Use of tobacco products, excessive alcohol, or dietary supplements and/or medications known to affect lipid metabolism
- Hypothyroidism or other disorders affecting lipid metabolism
- Any condition that would make it impossible to complete the study protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Missouri School of Medicine
Columbia, Missouri, United States, 65212
Actively Recruiting
Research Team
A
Amanda Heider
CONTACT
M
Mittendorfer Lab
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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