Actively Recruiting
Liposomal Bupivacaine for Pain After Lumbar Fusion
Led by Min Li · Updated on 2025-09-25
204
Participants Needed
1
Research Sites
66 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Spine surgery often causes severe postoperative pain. Currently, our hospital routinely uses ropivacaine for local infiltration analgesia (lasting 6-8 hours). This study evaluates liposomal bupivacaine, a novel long-acting local anesthetic providing up to 72 hours of pain relief, in patients undergoing posterior lumbar spine surgery. Through a randomized controlled design, we will compare the two drugs' effects on pain control within 72 hours and opioid consumption. Both regimens are guideline-recommended and safe.
CONDITIONS
Official Title
Liposomal Bupivacaine for Pain After Lumbar Fusion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- ASA physical status class I to III
- Scheduled for elective 1- or 2-level posterior lumbar surgery: decompression (laminectomy or discectomy) and fusion with internal fixation
You will not qualify if you...
- Chronic pain disorders requiring 30 mg or more oral morphine equivalents per day for more than 3 months
- Pre-existing neurological deficits affecting pain assessment
- Allergy or hypersensitivity to components of multimodal analgesia or local anesthetics such as bupivacaine or ropivacaine
- Acute systemic or local infection including surgical site infection or sepsis
- Metastatic spinal malignancies confirmed by imaging or histopathology
- Pregnancy or breastfeeding
- Patient refusal after protocol explanation
- Other high-risk conditions as determined by investigators
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Peking University Third Hospital
Beijing, China
Actively Recruiting
Research Team
M
Min Li
CONTACT
W
Wenwen Zhai
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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