Actively Recruiting
Liposomal Irinotecan With TAS102 and Bevacizumab for Patients With Metastatic Colorectal Cancer
Led by University of Wisconsin, Madison · Updated on 2026-04-02
50
Participants Needed
1
Research Sites
246 weeks
Total Duration
On this page
Sponsors
U
University of Wisconsin, Madison
Lead Sponsor
I
Ipsen
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is being done to see if combining liposomal irinotecan with TAS102 and bevacizumab confers clinical benefit for patients with treatment refractory metastatic colorectal cancer.
CONDITIONS
Official Title
Liposomal Irinotecan With TAS102 and Bevacizumab for Patients With Metastatic Colorectal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients must be 18 years of age or older
- Eastern Cooperative Oncology Group (ECOG) performance status must be 0 or 1
- Histologically or cytologically confirmed colorectal adenocarcinoma that is metastatic or unresectable
- Cancer must be mismatch repair proficient
- Prior treatment with 5-fluorouracil, oxaliplatin, and irinotecan containing regimens
- If RAS wild-type, prior anti-EGFR therapy with cetuximab or panitumumab
- If RAS wild-type and HER2 positive, prior HER2 targeted therapy
You will not qualify if you...
- Uncontrolled concurrent medical illness preventing completion of planned therapy
- Presence of BRAF V600 mutations in cancer
- Use of strong inducers or inhibitors of CYP3A4 within 2 weeks before starting therapy
- Mismatch repair deficient or microsatellite instability high cancers
- Prior treatment with TAS102
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Wisconsin Carbone Cancer Center
Madison, Wisconsin, United States, 52792
Actively Recruiting
Research Team
C
Cancer Connect
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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