Actively Recruiting
Liquid biopsiEs fOr luNg AllogRaft Damage classificatiOn - LEONARDO
Led by Jesper Magnusson · Updated on 2025-09-16
146
Participants Needed
1
Research Sites
315 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
LTx has the shortest survival of all solid organ transplants. The complex and time-demanding diagnostics of allograft dysfunction are a significant reason for this. The current study aims overarchingly to improve survival after lung transplantation (LTx) through precise and fast diagnostics. The specific aim is to develop direct-to-clinical implementation biomarkers for the most important aspects of long-term survival after LTx. An in-house-developed PCR-based cell-free-DNA methodology (cf-DNA) will be used for allograft damage and combined with specific other biomarkers to identify damage type. The current clinical golden standard for damage identification will be performed at every sampling instance. The research will be a single-centre prospective observational cohort study. The control samples at all time points will consist of the samples without allograft damage. Blood will be drawn at fixed time points and clinical events. All analyses will be performed at a separate lab, blinded to the patient's status. .
CONDITIONS
Official Title
Liquid biopsiEs fOr luNg AllogRaft Damage classificatiOn - LEONARDO
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Lung transplanted and followed up within the reach of the study participating centres.
- Good understanding to read and write within the languages in which the consent is provided.
You will not qualify if you...
- Not lung transplanted or not followed up within the reach of the study participating centres.
- No good understanding to read and write within the languages in which the consent is provided.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Sahlgrenska University hospital
Gothenburg, Västra Götaland County, Sweden, 413 45
Actively Recruiting
Research Team
J
Jesper M Magnusson, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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