Actively Recruiting
Liquid Biopsy-Based Pre-Screening to Streamline LDCT Lung Cancer Screening in High-Risk Individuals
Led by National University Hospital, Singapore · Updated on 2026-01-22
140
Participants Needed
1
Research Sites
217 weeks
Total Duration
On this page
Sponsors
N
National University Hospital, Singapore
Lead Sponsor
G
Gene Solutions
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study evaluates the feasibility and cost-effectiveness of using a blood-based liquid biopsy assay as a pre-screening tool before low-dose CT (LDCT) for lung cancer screening. By identifying individuals unlikely to have lung cancer, this approach aims to reduce unnecessary LDCT scans, radiation exposure, and healthcare costs, while improving early detection, particularly among high-risk individuals including never-smokers with a family history of lung cancer.
CONDITIONS
Official Title
Liquid Biopsy-Based Pre-Screening to Streamline LDCT Lung Cancer Screening in High-Risk Individuals
Who Can Participate
Eligibility Criteria
You may qualify if you...
- No prior history of lung cancer
- Current or former smoker aged 55-74 years with at least 30 pack-years smoking history and quit within the past 15 years; OR never-smoker aged 55-75 years with a first-degree family history of lung cancer
- Able and willing to provide written informed consent
- Aged 21 years or older for early-stage lung cancer patients with confirmed stage I-II lung cancer, treatment-naive
- Aged 21 years or older for advanced-stage lung cancer patients with confirmed stage III-IV lung cancer, treatment-naive
You will not qualify if you...
- Pregnant or breastfeeding women
- Inability or unwillingness to comply with study procedures
- Known allergy or contraindication to CT contrast agents (high-risk individuals only)
- Prior low-dose CT, CT thorax, or PET-CT within 12 months before enrollment (high-risk individuals only)
- Prior cancer-directed treatment for lung cancer (lung cancer cohorts only)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National University Hospital Singapore
Singapore, Singapore, 119228
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
SCREENING
Number of Arms
3
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