Actively Recruiting
Liquid Biopsy in Paraneoplastic Neurological Syndromes
Led by Heinrich-Heine University, Duesseldorf · Updated on 2026-03-24
60
Participants Needed
1
Research Sites
397 weeks
Total Duration
On this page
Sponsors
H
Heinrich-Heine University, Duesseldorf
Lead Sponsor
U
University of Regensburg
Collaborating Sponsor
AI-Summary
What this Trial Is About
The main objective of the study is to assess whether circulating tumor cells (CTCs) can be detected in the peripheral blood of patients with paraneoplastic neurological syndromes (PNS) by diagnostic leukapheresis (DLA) combined with the CELLSEARCH® System during clinical routine workup. If CTCs can be identified, a detailed molecular genetic analysis will be performed to characterize mutations in oncogenes and tumor suppressor genes. In addition, the study aims to analyze cell-free DNA (cfDNA) in serum of patients. Individuals with PNS and high- or intermediate-risk or GAD65-antibodies with a detectable tumor (PNS+T), PNS patients with high- or intermediate-risk or GAD65-antibodies without detectable tumor (PNS w/o T), and matched tumor patients without PNS (T w/o PNS) will be included in the study.
CONDITIONS
Official Title
Liquid Biopsy in Paraneoplastic Neurological Syndromes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with paraneoplastic neurological syndromes (PNS) and high- or intermediate-risk or GAD65-antibodies
- Patients with peripheral tumors without PNS
You will not qualify if you...
- Age below 18 years at the time of inclusion
- Any mental condition impairing the capacity to provide informed consent
- Presence of contraindications to diagnostic leukapheresis (DLA)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf
Düsseldorf, Germany, 40225
Actively Recruiting
Research Team
N
Nico Melzer, MD
CONTACT
S
Saskia Räuber, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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