Actively Recruiting
LIquid Biopsy to prEdict Responses To First-line immunotherapY in Metastatic Non-small Cell LUNG Cancer. LIBERTY LUNG
Led by Institut Curie · Updated on 2025-09-18
300
Participants Needed
3
Research Sites
471 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patient with histologically proven NSCLC in a metastatic stage, treatment naïve and eligible for first-line treatment with immune checkpoint inhibitor. Combination with chemotherapy is possible. Presence of a mutation after NGS analysis is required for ctDNA follow-up.
CONDITIONS
Official Title
LIquid Biopsy to prEdict Responses To First-line immunotherapY in Metastatic Non-small Cell LUNG Cancer. LIBERTY LUNG
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically-proven non-small cell lung cancer (NSCLC)
- Age 18 years or older
- Advanced or metastatic stage IV disease
- No prior treatment for NSCLC (treatment-nafve)
- Eligible for first-line treatment with immune checkpoint inhibitor
- Measurable disease by RECIST 1.1 criteria on CT scan
- PD-L1 expression available from tumor biopsy immunohistochemistry
- No ALK or EGFR gene alterations
- Tumor tissue available for next-generation sequencing (NGS) analysis (7 slides)
- Performance status 0 or 1
- Signed informed consent from the patient
You will not qualify if you...
- No social security affiliation
- Under legal protection
- Pregnant or breastfeeding women
- Participation in another clinical trial that modifies immunotherapy, immunotherapy/chemotherapy treatment, or study follow-up without informing the investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 3 locations
1
Hopital Ambroise Pare
Boulogne-Billancourt, France, 92100
Actively Recruiting
2
Institut Curie
Paris, France, 75005
Actively Recruiting
3
Institut Curie
Saint-Cloud, France, 92210
Actively Recruiting
Research Team
M
Marie-Emmanuelle Legrier
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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